Yellow fever
From MicrobeWiki, the student-edited microbiology resource
A Microbial Biorealm page on the genus Yellow fever Yellow fever
Contents |
Classification
Virus Classification is categorise in Group 4 positive Single-Stranded Ribonucleic Acid. Family: Flaviviridae Genus: Flavivirus Type of species: Yellow fever virus
higher order taxa
Family: Flavivirus
Species
Type of species: Yellow fever virus
Genus species
Description and significance
Yellow fever is a severe disease that is cause by mosquito bite. It is important because it has cause severe fever disease that are common in many African and many tropical countries.
Genome structure
Yellow Fever genome is a positive-stranded RNA molecule that contains 11.8 kb, with a 5’ cap structure and none-polyadenylated 3’ terminus. Translation of the single ORF encode on the viral genome results in the production of a precursor protein that is cleaved by host and viral proteases to produce the mature viral proteins.
Ecology
The virus can be found in some tropical areas of Africa and South America. The only way it contributes to the environment is by spreading the virus around.
Pathology
Yellow fever occur by a mosquito bite, after the mosquito have bitten what happened to the body is that the virus introduce to the blood stream via the saliva of the mosquito as it bite. The virus can then be transported and reproduce itself in a variety of the body's cells, usually the liver, kidneys and blood vessels.
In the beginning of the first week the virus stay still in the body meaning there is no sign and symptom for the first week. After the first week most patients usually have a fever, muscle pain, headache, shivers, and loss of appetite.
Current Research
Current research that started in may 2008 by prof. W.J.M Spaan is to analyse the function of conserved flaviviral RNA sequences and structures in the replication of these viruses. Focus on genetic analysis of the yellow fever NS1 protein. Another research that is being done now is to improve the existing Yellow fever 17D vaccines to sorting the different strain of yellow fever.
References
Clarke, D. H. and Casals, J.1958. Techniques for Haemagglutination and hamagglutination inhibition with arthropod-borne viruses. American Journal of Tropical Medicine and Hygiene vol. 7, p. 561-573. Corey L. Campbell, William C. Black IV, Ann M. Hess and Brian D. Foy. 2008. Comparative genomics of small RNA regulatory pathway component in vector mosquitoes. BMC Genomics Vol. 9 p425-444. John –Paul Mutebi, Alberto Gianella, Amelia Travassos da Rosa, Robert B. tesh Alan D. T. Barret and Stephen Higgs. 2004. Yellow Fever virus infectivity for Bolivian Aesdes aegypti mosquitoes. Emerging Infectious diseases P1657-1664.
Edited by student of Emily Lilly at University of Massachusetts Dartmouth.
