Bordetella parapertussis: Difference between revisions
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Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? | Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? | ||
Bordetella parapertussis typically possesses a single circular chromosome, with a genome size of approximately 4.7 million base pairs (Mbp) and a G+C content of 65%. Comparative genomic analysis has identified 81 single nucleotide polymorphisms and 13 short insertions and deletions compared to the reference genome B. parapertussis 12822, indicating ongoing evolutionary changes. | |||
This bacterium has diverged into two distinct lineages: one causing whooping cough in infants and the other infecting sheep. It shares a common ancestor with B. pertussis, both having evolved independently from B. bronchiseptica-like ancestors. | |||
Unlike B. pertussis, B. parapertussis is oxidase-negative, suggesting differences in respiratory mechanisms. It can utilize other oxidases in electron transport due to the absence of cytochrome c oxidase. | |||
A specific genome sequence, IRBP134, isolated from a fully vaccinated infant in Iran, was sequenced using Nextseq technology. The assembly generated 72 scaffolds with a genome size of 4,720,964 base pairs, including 4,620 potential coding sequences and 55 RNA sequences. The presence of 63 tRNAs and one large and one small subunit of ribosomal RNA was also identified in the genome annotation. [9] | |||
==Cell Structure, Metabolism and Life Cycle== | ==Cell Structure, Metabolism and Life Cycle== | ||
Revision as of 06:13, 24 April 2024
Classification
Domain: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus and Species: Bordetella parapertussis [1]
Species
Bordetella parapertussis
Description and Significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
Genome Structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
Bordetella parapertussis typically possesses a single circular chromosome, with a genome size of approximately 4.7 million base pairs (Mbp) and a G+C content of 65%. Comparative genomic analysis has identified 81 single nucleotide polymorphisms and 13 short insertions and deletions compared to the reference genome B. parapertussis 12822, indicating ongoing evolutionary changes.
This bacterium has diverged into two distinct lineages: one causing whooping cough in infants and the other infecting sheep. It shares a common ancestor with B. pertussis, both having evolved independently from B. bronchiseptica-like ancestors.
Unlike B. pertussis, B. parapertussis is oxidase-negative, suggesting differences in respiratory mechanisms. It can utilize other oxidases in electron transport due to the absence of cytochrome c oxidase.
A specific genome sequence, IRBP134, isolated from a fully vaccinated infant in Iran, was sequenced using Nextseq technology. The assembly generated 72 scaffolds with a genome size of 4,720,964 base pairs, including 4,620 potential coding sequences and 55 RNA sequences. The presence of 63 tRNAs and one large and one small subunit of ribosomal RNA was also identified in the genome annotation. [9]
Cell Structure, Metabolism and Life Cycle
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
References
[1] [Schoch CL, et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC: PMC7408187]
[9] Safarchi, A., Saedi, S., Tay, C. Y., Lamichhane, B., Nakhost Lotfi, M., & Shahcheraghi, F. (2022). Genome Characteristic of Bordetella parapertussis Isolated from Iran. Current microbiology, 79(10), 314. https://doi.org/10.1007/s00284-022-03009-x
Author
Page authored by Sachin Gupta and Erin Goertzen, students of Prof. Jay Lennon at Indiana University.
