Bacteria; Proteobacteria; Epsilon Proteobacteria; Campylobacterales; Helicobacteraceae
Description and Significance
Helicobacter cinaedi was first isolated in 1984 in rectal swabs from male homosexuals, whom most were immunocompromised . It has also been isolated from patients with enteritis and proctitis along with other species of its genus, such as H. fennelliae, H. pullorum,H. westmeadii, H. canadensis, and H. rappini . Helicobacter cinaedi was initially identified as Campylobacter cinaedi, until 1991 due to molecular analysis . It most commonly causes enteric and extraintestinal diseases .
Structure, Metabolism, and Life Cycle
Helicobacter cinaedi is a non-spore forming gram-negative bacterium. Like H. pylori, H. mustelae, and H. fennelliae, it has a G-C value between 35 to 40 mol%. It exhibits a darting motility by use of a single sheathed flagellum. Its fatty acid composition includes tetradecanoic acid, hexadecanoic acid and octadecenois acid . Unlike Helicobacter pylori, Helicobacter cinaedi does not produce urease .
Ecology and Pathogenesis
Helicobacter cinaedi is found normally in the intestinal flora of hamsters . It can cause bacteraemia, diarrhea and focal colonic lesions in humans. Cellulitis and arthritis is seen in a high percentage of patients infected with Helicobacter cinaedi. It is seen to be resistant to ciprofloxacin but treatment with tetracycline and various aminoglycosides is successful .
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Page authored by Megan Twite, student of Mandy Brosnahan, Instructor at the University of Minnesota-Twin Cities, MICB 3301/3303: Biology of Microorganisms.