Difference between revisions of "Acinetobacter"

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'''NCBI:<br />[http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=469&lvl=3&lin=f&keep=1&srchmode=1&unlock Taxonomy]<br /> Genome '''
 
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<h2>Classification</h2><br>
 
<h2>Classification</h2><br>
 
[[image:Acinetobacter.jpg|frame|right|''Acinetobacter'' sp.[http://www.denniskunkel.com/product_info.php?products_id=847&osCsid=e865469d89e27c24e46355a0f2932e0d Image from Dennis Kunkel Microscopy, Inc.]]]
 
[[image:Acinetobacter.jpg|frame|right|''Acinetobacter'' sp.[http://www.denniskunkel.com/product_info.php?products_id=847&osCsid=e865469d89e27c24e46355a0f2932e0d Image from Dennis Kunkel Microscopy, Inc.]]]

Revision as of 13:47, 14 August 2006

A Microbial Biorealm page on the Acinetobacter

NCBI:
Taxonomy
Genome

{

Classification


Higher order taxa:

Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae

Species:

Acinetobacter baumannii
Acinetobacter baylyi
Acinetobacter bouvetii
Acinetobacter calcoaceticus

Description and Significance

Acinetobacter is a genus of opportunistic pathogens in the proteobacteria group, species of which are distributed in widespread, diverse habitats. It has garnered media attention because of an outbreak among soldiers in Iraq who contracted the species Acinetobacter baumannii from the Iraqi soil. At least 280 people, mostly soldiers returning from the battlefield, were infected with the disease, and at least 5 (non-active-duty soldiers) died.

These bacteria can often be found as the cause of pneumonia in hospitalized patients, especially those dependent on ventilators in Intensive Care Units. The bacteria are most often contracted through the exposure of open wounds to contaminated soil. This makes it a problem during warfare (it was the second-leading cause of infection among troops during the Vietnam conflict) because of the high number of injuries caused by explosives, which can easily lead to dirtying exposed skin. In healthy humans, it is normal to have some amount of Acinetobacter on the skin surface; as many as 25% of healthy adults do in fact harbor these bacteria.

Genome Structure

While there is much information available on the types of infections Acinetobacter causes, relatively few studies have been performed on the bacteria's genetics. Because Acinetobacters are very resistant to antibiotics and are difficult to differentiate between species when isolated from patients, learning more about their DNA will help develop better drugs to control outbreaks of the infection.


Cell Structure and Metabolism









Acinetobacter cells are short, Gram-negative rods, measuring 1.0-1.5 by 1.5-2.5 microns during growth; they often become more coccoid during the stationary phase. Cells are found in pairs or small clusters; the groups form smooth, pale colonies on solid media. All species are strictly aerobic, catalase positive, and oxidase negative; it is the last test which is most used to distinguish Acinetobacter from other infective bacteria. These bacteria can use a varied selection of organic materials as sources of carbon.

Ecology

Acinetobacters are widely distributed in hospitals, where they pose the danger of transferring resistance to other hospital-inhabiting bacteria. They are found in soil, water, and in living organisms, where they may or may not be pathogenic. Up to 27% of hospital sink traps and 20% of hospital floor swabs have yielded isolates of Acinetobacter. The bacteria has been found to contaminate respirators and hospital air when there are colonized patients present, as well as nearby bed blankets and bed curtains. Currently studies are being performed on methods for hospital air purification in order to lower the prevalence of these pathogens among compromised patients.

References

Acinetobacter. Houston Medical School, University of Texas. 1995.

Herper, Matthew. The Iraq Infection. Forbes.com, August 2 2005.

Bergogne-Berezin, E. et al. Acinetobacter spp. as Nosocomial Pathogens: Microbiological, Clinical, and Epidemiological Features. Clinical Microbiology Reviews April 1996. 148-165.