Difference between revisions of "Bilophila wadsworthia"

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cellular organisms; Bacteria; Proteobacteria; delta/epsilon subdivisions; Deltaproteobacteria; Desulfovibrionales; Desulfovibrionaceae; Bilophila; Bilophila wadsworthia

Bilophila wadsworthia

Description and Significance

Bilophila wadsworthia is a gram negative anaerobic rod [1]. This bacteria carries out fermentation within the gut using taurine as the final electron acceptor [2]. It is urease-positive, bile resistant, catalase-positive [3]. It is largely found in patients that have appendicitis [3]. It has been found to be penicillin resistant by changing its binding site for it. This has made the organism of clinical importance [2].

Structure, Metabolism, and Life Cycle

This organism does not have a capsule and it also uses hydrogen as a growth substrate [2]. It has a 92% genomic DNA homology and is a bacteria. It also is a common, non-pathogenic organism growing in the colon of human and pigs and is slow to form its colonies [4]. At this time, the exact life cycle of Bilophila wadsworthia is unknown.

Ecology and Pathogenesis

Bilophila wadsworthia is normal flora in human feces and can be found occasionally in the saliva and vagina [3]. [This organism has been found to cause intra-abdominal abscesses and has been found in human feces. It was also found in the peridontal pockets of dogs as well [1]. The specific virulence factor of this organism is something that has yet to be determined [1]. The organism is commonly found in patients that have appendicitis and are experiencing stomach pain as the appendicitis has turned severe.


[1] Baron,E. 1996. "Bilophila wadsworthia a Unique Gram-negative Anaerobic Rod.""Anaerobe".3:83–86. http://www.afrh.fr/web-content/documents/Basedocumentairemedicale/1997/1997%20B.Wadsworthia%20Bacteria%20HS%20Baron.pdf


[2] Silva,S.;Venceslau,S.;Fernandes,C;Valente,F;Pereira,I. 2008. "Hydrogen as an energy source for the human pathogen Bilophila wadsworthia"."Antonie van Leeuwenhoek".93:381-390. http://link.springer.com/article/10.1007%2Fs10482-007-9215-x


[3] Finegold S, Summanen P, Hunt Gerardo S, Baron E. 1992. "Clinical importance of Bilophila wadsworthia". "Eur J Clin Microbiol Infect Dis".11:1058-63. http://www.ncbi.nlm.nih.gov/pubmed/1295759


[4] McOrist,S.; Keller,L.; and McOrist,A. 2003. "Search for Lawsonia intracellularis and Bilophila wadsworthia in malabsorption-diseased chickens". "Can J Vet Res".3: 232–234. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC227059/


Page authored by Elise Wildrig, student of Mandy Brosnahan, Instructor at the University of Minnesota-Twin Cities, MICB 3301/3303: Biology of Microorganisms.