Bunyaviridae

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Baltimore Classification

Higher order taxa

Virus; ssRNA negative-strand viruses; Bunyaviridae

Genera

Hantavirus, Orthobunyavirus, Nairovirus, Phlebovirus, Topsovirus

Description and Significance

Bunyaviridae is the largest family of viruses, with over 200 species.

Genome Structure

The bunyavirus genome is monomeric and consists of three segments of linear negative-sense (or ambisense, depending on the genus) RNA. The terminal sequences of each segment are base-paired. Because of this, the RNAs form non-covalently closed circles. The nucleotide sequences at the3'-terminus and the 5'-terminus are complimentary, forming panhandle structures. The 5'-terminus is not capped.

The complete genome is 10500-22700 nucleotides long. The three segments of the genome are labeled L, M, and S. The L segment is 6300-12000 nucleotides long and encodes the viral RNA polymerase. The M segment is 3500-6000 nucleotides long and encodes two glycoproteins as a single gene product that is usually co-translationally cleaved. The S segments is 1000-2200 nucleotides long and encodes the coat protein.

Virion Structure of a Bunyavirus

Reproduction Cycle of a Bunyavirus in a Host Cell

Viral Ecology & Pathology

References. Updated June 13, 2006

Descriptions of Plant Viruses: Notes on Family: Bunyaviridae

ICTVdB - The Universal Virus Database, version 3. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Microbiology @ Leicester: Virology: Bunyaviruses