Difference between revisions of "Cornebacterium mastitidis"

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(8. Current Research)
(8. Current Research)
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=8. Current Research=
 
=8. Current Research=
 
Include information about how this microbe (or related microbes) are currently being studied and for what purpose
 
Include information about how this microbe (or related microbes) are currently being studied and for what purpose
  C. mastitidis was recently discovered as an important immunoresponse factor in ocular health of mice [3]. Using a mouse model of an ocular surface, C mastitidis was isolated and proved to play a role in the immunological response to several eye infections [2]. C. mastitidis was found to have a commensal relationship with the ocular microbiome by initiating the production of interleukin-17 by γδ T cells in the ocular mucosa [3]. The interleukin-17 response induces the recruitment of neutrophil into the conjunctiva, which then releases antimicrobial molecules into the tears. The antimicrobial molecules protect against invasive infections like Candida albicans and Pseudomonas aeruginosa [3]. This immune response initiated by C. mastitidis was found to be essential to the local ocular immunity in the mice that had been exposed to the bacterium. While a consistent ocular microbiome signature is lacking and controversial due to the constant tear washing and antimicrobial environment of the eye, C. mastitidis was found to have the ability to colonize the ocular surface of both humans and mice [3]. The role of C. mastitidis in the conjunctiva immune response sets a platform for future research in the ocular microbiome and the diseases that originate there [3].
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C. mastitidis was recently discovered as an important immunoresponse factor in ocular health of mice [3]. Using a mouse model of an ocular surface, C mastitidis was isolated and proved to play a role in the immunological response to several eye infections [2]. C. mastitidis was found to have a commensal relationship with the ocular microbiome by initiating the production of interleukin-17 by γδ T cells in the ocular mucosa [3]. The interleukin-17 response induces the recruitment of neutrophil into the conjunctiva, which then releases antimicrobial molecules into the tears. The antimicrobial molecules protect against invasive infections like Candida albicans and Pseudomonas aeruginosa [3]. This immune response initiated by C. mastitidis was found to be essential to the local ocular immunity in the mice that had been exposed to the bacterium. While a consistent ocular microbiome signature is lacking and controversial due to the constant tear washing and antimicrobial environment of the eye, C. mastitidis was found to have the ability to colonize the ocular surface of both humans and mice [3]. The role of C. mastitidis in the conjunctiva immune response sets a platform for future research in the ocular microbiome and the diseases that originate there [3].
  
 
=9. References=
 
=9. References=
 
It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page.
 
It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page.
 
[Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.
 
[Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.

Revision as of 14:44, 10 December 2018

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1. Classification

a. Higher order taxa

Domain; Phylum; Class; Order; Family; Genus Include this section if your Wiki page focuses on a specific taxon/group of organisms

2. Description and significance

Describe the appearance, habitat, etc. of the organism, and why you think it is important.

  • Include as many headings as are relevant to your microbe. Consider using the headings below, as they will allow readers to quickly locate specific information of major interest*

3. Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?

4. Cell structure

Interesting features of cell structure. Can be combined with “metabolic processes”

5. Metabolic processes

Describe important sources of energy, electrons, and carbon (i.e. trophy) for the organism/organisms you are focusing on, as well as important molecules it/they synthesize(s).

6. Ecology

Habitat; symbiosis; contributions to the environment.

7. Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

8. Current Research

Include information about how this microbe (or related microbes) are currently being studied and for what purpose

C. mastitidis was recently discovered as an important immunoresponse factor in ocular health of mice [3]. Using a mouse model of an ocular surface, C mastitidis was isolated and proved to play a role in the immunological response to several eye infections [2]. C. mastitidis was found to have a commensal relationship with the ocular microbiome by initiating the production of interleukin-17 by γδ T cells in the ocular mucosa [3]. The interleukin-17 response induces the recruitment of neutrophil into the conjunctiva, which then releases antimicrobial molecules into the tears. The antimicrobial molecules protect against invasive infections like Candida albicans and Pseudomonas aeruginosa [3]. This immune response initiated by C. mastitidis was found to be essential to the local ocular immunity in the mice that had been exposed to the bacterium. While a consistent ocular microbiome signature is lacking and controversial due to the constant tear washing and antimicrobial environment of the eye, C. mastitidis was found to have the ability to colonize the ocular surface of both humans and mice [3]. The role of C. mastitidis in the conjunctiva immune response sets a platform for future research in the ocular microbiome and the diseases that originate there [3].

9. References

It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page. [Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.