Effects of Pathogen-Vector Interactions on the Transmission of Dengue Virus: Difference between revisions
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== | ==Vector host-factors that affect DENV replication and transmission in the mosquito vector== | ||
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Some of the host factors that specifically influence dengue infection and transmission are <I>Aedes</I> innate immune system response to viral infection and vector immune response to co-infection of dengue virus and the parasitic bacterium <I>wolbachia</I> [4,6,13]. | |||
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==Innate Immune Response of Vector== | |||
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mean virus titer in mosquitoes can be modulated by blocking the function of one or more components in the RNA interference (RNAi) pathway. This innate immune response is triggered in an infected cell by the presence of dsRNA. In the case of DENV infection the secondary structure of the NTR of the RNA genome may trigger this response. The hairpin loops as seen in figure (the structure one) look like dsRNA[24]. Activation of the RNAi pathway leads to the degradation of dsRNA within the infected cell and although it does not completely inhibit infection, virus titers are lower in mosquito cells with a functional RNAi response as opposed to mosquito cells without a functional response [24]. | |||
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Besides RNAi, mosquitoes | |||
==Effects of <I>Wolbachia</I> on Dengue Replication and Transmission in Vector Host== | |||
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Revision as of 20:08, 7 December 2010
Vector host-factors that affect DENV replication and transmission in the mosquito vector
Some of the host factors that specifically influence dengue infection and transmission are Aedes innate immune system response to viral infection and vector immune response to co-infection of dengue virus and the parasitic bacterium wolbachia [4,6,13].
Innate Immune Response of Vector
mean virus titer in mosquitoes can be modulated by blocking the function of one or more components in the RNA interference (RNAi) pathway. This innate immune response is triggered in an infected cell by the presence of dsRNA. In the case of DENV infection the secondary structure of the NTR of the RNA genome may trigger this response. The hairpin loops as seen in figure (the structure one) look like dsRNA[24]. Activation of the RNAi pathway leads to the degradation of dsRNA within the infected cell and although it does not completely inhibit infection, virus titers are lower in mosquito cells with a functional RNAi response as opposed to mosquito cells without a functional response [24].
Besides RNAi, mosquitoes
Effects of Wolbachia on Dengue Replication and Transmission in Vector Host