Group IV. (+) Sense single-stranded RNA viruse
Higher Order Categories
Description and Significance
Infection with Flavivirus may lead to Dengue(DF), or Dengue Hemorrhagic Fever (DHF). Both of these are serious disease processes that have lead to major epidemics throughout history. The first reported epidemics of Dengue occurred between 1779 and 1780 over continents as far apart as North America, Africa, and Asia . Although, historically, outbreaks of dengue have been widespread, the disease process has not always been considered fatal in healthy adults . Infection of Flavivirus can be deadly, however, when it leads to hemorrhagic fever or dengue shock syndrome .
Dengue fever continues to be a problem in some part of the world, yet no vaccines have been developed and tested on humans . In addition, 50 to 100 million individuals are infected with dengue every year . For this reason, it is important to continue researching this virus.
Flavivirus capsids contain a single-stranded, positive-sense RNA molecule of approximately 10,700 base pairs. This genome is then surrounded by a nucleocapsid . This genome consists of one open reading-frame that encodes a precursor polyprotein . This polyprotein is altered both during and after translation to produce 10 proteins .
Virion Structure of a Flavivirus
Reproductive Cycle of a Flavivirus in a Host Cell
Viral Ecology and Pathology
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