Fusobacterium nucleatum

From MicrobeWiki, the student-edited microbiology resource

A Microbial Biorealm page on the genus Fusobacterium nucleatum

Classification

Higher order taxa

root; cellular organisms; Bacteria; Fusobacteria; Fusobacteria (class); Fusobacteriaceae; Fusobacterales; Fusobacterium

Genus

Fusobacterium


NCBI: Taxonomy

Description and significance

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated. Include a picture or two (with sources) if you can find them.


Fusobacterium nucleatum is a bacterium that is commonly found in the dental plaque of humans and is frequently associated with gum disease. The cells of F. nucleatum are fusiform rods or spindle-shaped of many different lengths. F. nucleatum is found in the dental plaque of many primates, thus includes man. This bacteria has been experimented to play a central role in dental plaque formation. This is due to its ability to adhere to a wide range of both Gram-positive and Gram-negative plaque microorganisms, such as Porphyromonas gingivalis. F. nucleatum is very much associated with periodontitis, along with invasive human infections of the head and neck, chest, lung, liver and abdomen. Due to its adherence ability, it can be associated with viruses, which adhere to host tissue cells as an invasion and modulate the host's immune response.

Native plasmids have been identified in strains of F. nucleatum. Using one of the native plasmid pFN1, a F. nucleatum - E. coli shuttle vector has been developed.

The pathogenic potential of Fusobacterium nucleatum and its significance in the development of periodontal diseases, as well as in infections in other organs, have gained new interest for several reasons. First, this bacterium has a very high chance to be pathogenic because of its high frequency in periodontal lesions, its production of irritants that affect the tissue, its ability to share synergisms with other bacteria in mixed infections, and its ability to form numerous aggregates with other suspected pathogens in periodontal disease(therefore, it acts as a bridge between early and late colonizers on surfaces of teeth). Second, F. nucleatum is the most common in clinical infections of other body sites. Third, recent new techniques have made it possible to obtain more information about F. nucleatum on the genetic level, thereby also gaining better knowledge of the structure and functions of the outer membrane proteins, which are of great interest with respect to coaggregation, cell nutrition, and antibiotic susceptibility.


Fusobacterium nucleatum ATCC23726 is one type of Fusobacterium nucleatum that is still having its full assembly in progress.

Genome structure

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Bacillus Licheniformis is a Gram positive, thermophillic bacterium. Its optimal growth temperature is 50°C, but it can also survive at much higher temperatures. Its optimal temperature for

Cell structure and metabolism

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Ecology

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Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

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References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by Jason Homan, student of Rachel Larsen and Kit Pogliano