Helicobacter hepaticus ATCC51449

From MicrobeWiki, the student-edited microbiology resource

A Microbial Biorealm page on the genus Helicobacter hepaticus ATCC51449


Higher order taxa

Cellular Organisms; Bacteria; Proteobacteria; Delta/Epsilon Subdivisions; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter; Helicobacter hepaticus ATCC51449


Helicobacter hepaticus

NCBI: Taxonomy Genome: H. hepaticus ATCC51449

Description and significance

Helicobacter hepaticus ATCC514459 is a Gram-negative, spiral shaped bacteria. It can have one to seven spirals and it has bipolar, sheathed flagella. It is usually between 0.2 to 0.3 µm in diameter and 1.5 to 5.0 µm long. It is a microaerophilic organism since it requires oxygen to live, but can live at environments that contain less oxygen than atmospheric levels. Like other species of Helicobacter, Helicobacter hepaticus, can be found in the mucosal layer of the gastrointestinal tract or in liver tissue. In mice, it has been found to cause chronic hepatitis, liver cancer, and inflammatory bowel disease. Its importance in humans is not fully understood yet. (EMBL-EBI)

Helicobacter hepaticus was first isolated from hepatic tissue by when a spiral bacteria was able to be cultivated on blood agar plates incubated at 37ºC under anaerobic or microaerobic conditions. Ultrastructural morphologic examination, biochemical characteristics examination, and 16S rRNA gene sequencing were all used to characterize Helicobacter hepaticus. (Rice 129-30)

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.


Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.


How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required


Rice, Jerry M. "Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice." Emerging Infectious Diseases. 1995. Volume 1, No. 4. p. 129-31. ftp://ftp.cdc.gov/pub/EID/vol1no4/adobe/rice.pdf


[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by Arpan Patel, a student of Rachel Larsen