Helicobacter hepaticus ATCC51449

From MicrobeWiki, the student-edited microbiology resource

A Microbial Biorealm page on the genus Helicobacter hepaticus ATCC51449


Higher order taxa

Cellular Organisms; Bacteria; Proteobacteria; Delta/Epsilon Subdivisions; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter; Helicobacter hepaticus ATCC51449


Helicobacter hepaticus

NCBI: Taxonomy Genome: H. hepaticus ATCC51449

Description and significance

Helicobacter hepaticus ATCC514459 is a Gram-negative, spiral shaped bacteria. It can have one to seven spirals and it has bipolar, sheathed flagella. It is usually between 0.2 to 0.3 µm in diameter and 1.5 to 5.0 µm long. It is a microaerophilic organism since it requires oxygen to live, but can live at environments that contain less oxygen than atmospheric levels. Like other species of Helicobacter, Helicobacter hepaticus, can be found in the mucosal layer of the gastrointestinal tract or in liver tissue. In mice, it has been found to cause chronic hepatitis, liver cancer, and inflammatory bowel disease. Its importance in humans is not fully understood yet. (EMBL-EBI)

Helicobacter hepaticus was first isolated from hepatic tissue by when a spiral bacteria was able to be cultivated on blood agar plates incubated at 37ºC under anaerobic or microaerobic conditions. Ultrastructural morphologic examination, biochemical characteristics examination, and 16S rRNA gene sequencing were all used to characterize Helicobacter hepaticus. (Rice 129-30)

Genome structure

Helicobacter hepaticus has a circular genome consisting of 1,799,146 base pairs, which are thought to encode for 1,875 proteins. It has a 35.9% GC content and 938 of its proteins have orthologs with Helicobacter pylori, 953 are orthologous with Campylobacter jejuni, and 821 are orthologous with both H. pylori and C. jejuni. The genome also contains a 71 kb genomic island HHGI1. The genomic island encodes three components of a type IV secretion system. A type IV secretion system is a conjugation system that allows for the transporting of DNA or proteins. Five other strains of Helicobacter hepaticus that are known to cause liver disease lacked anywhere from 85 to 229 genes, including large parts of the genomic island HHGI1. (Suerbaum S)

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.


Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.


How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required


Rice, Jerry M. "Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice." Emerging Infectious Diseases. 1995. Volume 1, No. 4. p. 129-31. ftp://ftp.cdc.gov/pub/EID/vol1no4/adobe/rice.pdf

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by Arpan Patel, a student of Rachel Larsen