Higher order taxa:
Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania
Leishmania major, L. donovani, L. braziliensis
Description and Significance
Leishmania is a parasite which causes human leishmaniasis. The genus Leishmania is unique among parasites in that its species are divided based not on the form and structure of the cells, but rather on the pathology and symptoms of the disease they cause. Leishmania may infect many vertebrates, but in human hosts the infection most frequently stems from the bites of sand fly vectors or, in the case of Leishmania major, from gerbils and other small rodent vectors. Leishmaniasis can take three forms: dermal cutaneous leishmaniasis, visceral leishmaniasis, and mucocutaneous leishmaniasis. Dermal cutaneous leishmaniasis, generated by Leishmania major, causes sores on the human host's skin, which range in appearance and degree of discomfort. The sores are treatable with antibiotics and preventable with vaccination. Visceral leishmaniasis, produced by Leishmania donovani, is identified by an enlargement of the liver and spleen; symptoms include breathing difficulties, edema, diarrhea, and bleeding mucus membranes. If untreated for an extended period of time, visceral leishmaniasis may result in death. Mucocutaneous leishmaniasis, caused by Leishmania braziliensis, initially yields topical sores at the time of the vector bite, however secondary infections may lead to permanently disfiguring ulcerations in the mucus cavities of the mouth and nose.
Leishmania major's genome Friedlin has been sequenced, and is found to have a 32.8mb genome with 36 chromosomes and a G+C content of approx. 63%. For a complete table of sequenced data of the Leishmania major genome Friedlin, click here.
Cell Structure and Metabolism
Leishmanias promastigote form (found in the vector) is similar to the amastigote, but possesses a prominent flagella. The surface membrane has binding site molecules such as glycoproteins, and manose receptors have also been detected. These are important in the uptake of the promastigotes by macrophages in the host cell. Antibodies in the host serum bind to the promastigotes and facilitate uptake and entry into the macrophage. The macrophages have Fc receptors on their surface. Upon losing the flagella (see life cycle, below) Leishmanias amastigote form (found in the cells of the vertebrate host) is spherical and is contained within a parasitophorus vacuole within a macrophage. There is a prominent nucleus and kinetoplast, and the vacuolated cytoplasm contains lysosomes. The outer membrane has a polysaccharide component but there is no surface coat.Once inside the host cell, Leishmania is able to protect itself from powerful host immunities by using several unique defense mechanisms, including its rapid cell division. Leishmania is a heterotophic organism whose prominent flagella may allow it to puncture host cells, allowing the promastigote to consume nutrients and obtain energy from the cell sap.
The Leishmania parasite is found in 88 countries, in Central and South America, Mexico, southern Europe (very rarely), the Middle East, parts of Asia, and primarily eastern and northern Africa. Its habitat ranges from tropical rainforests to arid regions, depending on the type of vector (predominantly insect or rodent) each particular species inhabits. Leishmania is transported between vertebrate hosts through vector bites and causes cell disruption and subsequent illness in its host.
For more information on parasites similar to Leishmania, see Trypanosoma.