https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&feed=atom&action=history
Marburgvirus - Revision history
2024-03-28T19:25:26Z
Revision history for this page on the wiki
MediaWiki 1.39.6
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=56127&oldid=prev
Blaylock: Corrected claimed magnification of image to match that of source. But see my comments that I will add in the discussion page…
2010-11-18T10:16:15Z
<p>Corrected claimed magnification of image to match that of source. But see my comments that I will add in the discussion page…</p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome Structure==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome Structure==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Marburg2.jpg|frame|Negative stain image of an isolate of Marburg virus, <del style="font-weight: bold; text-decoration: none;">1000x </del>magnification. Note filamentous particles [4]. ]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Marburg2.jpg|frame|Negative stain image of an isolate of Marburg virus, <ins style="font-weight: bold; text-decoration: none;">100,000x </ins>magnification. Note filamentous particles [4]. ]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Filoviruses are enveloped, nonsegmented negative-stranded RNA viruses. The two species, Marburg and Ebola virus, are genetically distinct with 7 genes and a total molecular length of approximately 19 kb (19112 bp), making them the owners of the largest known genomes of negative-strand RNA viruses. The virions appear long and filamentous, occasionally branched. In addition, the virions may appear as "6"-shaped, "U"-shaped, or circular configurations. [1][2]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Filoviruses are enveloped, nonsegmented negative-stranded RNA viruses. The two species, Marburg and Ebola virus, are genetically distinct with 7 genes and a total molecular length of approximately 19 kb (19112 bp), making them the owners of the largest known genomes of negative-strand RNA viruses. The virions appear long and filamentous, occasionally branched. In addition, the virions may appear as "6"-shaped, "U"-shaped, or circular configurations. [1][2]</div></td></tr>
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Blaylock
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=56122&oldid=prev
Adenjust: /* Author */
2010-11-11T14:44:37Z
<p><span dir="auto"><span class="autocomment">Author</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:44, 11 November 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Author==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Author==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Page authored by <del style="font-weight: bold; text-decoration: none;">Justin Aden </del>& Janeen Anderson, student of [http://www.kbs.msu.edu/faculty/lennon/ Prof. Jay Lennon] at Michigan State University.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Page authored by <ins style="font-weight: bold; text-decoration: none;">J.A. </ins>& Janeen Anderson, student of [http://www.kbs.msu.edu/faculty/lennon/ Prof. Jay Lennon] at Michigan State University.</div></td></tr>
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Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=55129&oldid=prev
BarichD at 18:59, 25 August 2010
2010-08-25T18:59:42Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Classification==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Classification==</div></td></tr>
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BarichD
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43374&oldid=prev
Adenjust: /* Author */
2009-04-22T13:17:59Z
<p><span dir="auto"><span class="autocomment">Author</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:17, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Author==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Author==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Page authored by Justin Aden, student of [http://www.kbs.msu.edu/faculty/lennon/ Prof. Jay Lennon] at Michigan State University.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Page authored by Justin Aden <ins style="font-weight: bold; text-decoration: none;">& Janeen Anderson</ins>, student of [http://www.kbs.msu.edu/faculty/lennon/ Prof. Jay Lennon] at Michigan State University.</div></td></tr>
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Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43373&oldid=prev
Adenjust: /* Classification */
2009-04-22T10:08:48Z
<p><span dir="auto"><span class="autocomment">Classification</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:08, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Classification==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Classification==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Viruses<del style="font-weight: bold; text-decoration: none;">; ssRNA viruses</del>; ssRNA negative-strand viruses; Mononegavirales; Filoviridae</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Species===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Species===</div></td></tr>
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Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43372&oldid=prev
Adenjust: /* Virion Structure and Life Cycle */
2009-04-22T10:08:05Z
<p><span dir="auto"><span class="autocomment">Virion Structure and Life Cycle</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:08, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. Filovirus genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane with widely spaced surface projections for host attachment, two matrix proteins, and the nucleocapsid proteins.[9]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Filovirus genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane with widely spaced surface projections for host attachment, two matrix proteins, and the nucleocapsid proteins.[9]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Marburg virions attach to a host cell and enter through endocytosed vesicles. When the virus membrane fuses with the vesicle membrane, the nucleocapsid is released into the cytoplasm. Viral RNA is then translated by employing the hosts mechanisms. Translation is switched over to replication when viral protein levels rise. The negative-sense RNA is used as a template to create a complimentary positive-sense strand of RNA, which is then used to synthesize negative-sense RNA for encapsidation. The newly-formed nucleocapsids have helical symmetry and are elongated.[6] Nucleocapsids bud from the host cell wall obtaining an envelope, and are released to find a new host cell. (source: [[Filoviridae]]) These Marburg virions measure about 80nm in diameter and optimally 790nm in length.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Marburg virions attach to a host cell and enter through endocytosed vesicles. When the virus membrane fuses with the vesicle membrane, the nucleocapsid is released into the cytoplasm. Viral RNA is then translated by employing the hosts mechanisms. Translation is switched over to replication when viral protein levels rise. The negative-sense RNA is used as a template to create a complimentary positive-sense strand of RNA, which is then used to synthesize negative-sense RNA for encapsidation. The newly-formed nucleocapsids have helical symmetry and are elongated.[6] Nucleocapsids bud from the host cell wall obtaining an envelope, and are released to find a new host cell. (source: [[Filoviridae]]) These Marburg virions measure about 80nm in diameter and optimally 790nm in length.</div></td></tr>
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Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43371&oldid=prev
Adenjust: /* Description and Significance */
2009-04-22T10:07:05Z
<p><span dir="auto"><span class="autocomment">Description and Significance</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description and Significance==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description and Significance==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Marburg is an extremely dangerous virus as it has a human fatality rate of 25-90%, with outbreaks that are impossible to predict or prevent.[1][7] Marburgvirus was the first ever filovirus recognized, discovered in 1967 when laboratory workers in Marburg, Germany developed hemorrhagic fever after handling tissue of African green monkeys from Uganda. The 1967 outbreak proved fatal in seven of the 37 cases. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Marburg is an extremely dangerous virus as it has a human fatality rate of 25-90%, with outbreaks that are impossible to predict or prevent.[1][7] Marburgvirus was the first ever filovirus recognized, discovered in 1967 when laboratory workers in Marburg, Germany developed hemorrhagic fever after handling tissue of African green monkeys from Uganda. The 1967 outbreak proved fatal in seven of the 37 cases. </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In 1975 the virus reemerged in Johannesburg, South Africa in a person who had been traveling in Zimbabwe. Several other cases of Marburg occurred sporadically through 1980, all of patients who had been recently traveling in Africa. In 1998, an outbreak occurred in Congo amongst individuals who had been working in a gold mine. In all cases, attempts to isolate the virus from all locations were unsuccessful. The virus has been appearing sporadically throughout parts of Africa since. In Angola from October 2004 to August 2005 for instance, an outbreak of Marburg occurred leaving 329 of 374 infected people dead (88% mortality). Cases of Marburgvirus continue to be rare and random, though most recently occurring in 2008 in Colorado of a man who had been traveling in Uganda.[7]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In 1975 the virus reemerged in Johannesburg, South Africa in a person who had been traveling in Zimbabwe. Several other cases of Marburg occurred sporadically through 1980, all of patients who had been recently traveling in Africa. In 1998, an outbreak occurred in Congo amongst individuals who had been working in a gold mine. In all cases, attempts to isolate the virus from all locations were unsuccessful. The virus has been appearing sporadically throughout parts of Africa since. In Angola from October 2004 to August 2005 for instance, an outbreak of Marburg occurred leaving 329 of 374 infected people dead (88% mortality). </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Cases of Marburgvirus continue to be rare and random, though most recently occurring in 2008 in Colorado of a man who had been traveling in Uganda.[7]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The only other filovirus is the Ebola virus, which claims an even higher mortality rate, discovered after Marburg in 1976.[3] The natural origins of both remain a complete mystery to this day and a cause of major concern and research.[1]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>The only other filovirus is the Ebola virus, which claims an even higher mortality rate, discovered after Marburg in 1976.[3] The natural origins of both remain a complete mystery to this day and a cause of major concern and research.[1]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43370&oldid=prev
Adenjust: /* Virion Structure and Life Cycle */
2009-04-22T09:56:36Z
<p><span dir="auto"><span class="autocomment">Virion Structure and Life Cycle</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:56, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. <del style="font-weight: bold; text-decoration: none;">The </del>genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane with widely spaced surface projections for host attachment, two matrix proteins, and the nucleocapsid proteins.[9] Marburg virions <del style="font-weight: bold; text-decoration: none;">measure about 80nm in diameter </del>and <del style="font-weight: bold; text-decoration: none;">optimally 790nm in length</del>. <del style="font-weight: bold; text-decoration: none;">Nucleocapsids </del>have helical symmetry and are elongated.[6] <del style="font-weight: bold; text-decoration: none;">As true of any virus, Marburg cannot survive without a </del>host<del style="font-weight: bold; text-decoration: none;">. During replication</del>, <del style="font-weight: bold; text-decoration: none;">newly copied virions accumulate rapidly in densely packed clusters </del>and <del style="font-weight: bold; text-decoration: none;">eventually burst out of the cell </del>to find a new host.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Filovirus </ins>genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane with widely spaced surface projections for host attachment, two matrix proteins, and the nucleocapsid proteins.[9]</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Marburg virions <ins style="font-weight: bold; text-decoration: none;">attach to a host cell </ins>and <ins style="font-weight: bold; text-decoration: none;">enter through endocytosed vesicles. When the virus membrane fuses with the vesicle membrane, the nucleocapsid is released into the cytoplasm. Viral RNA is then translated by employing the hosts mechanisms. Translation is switched over to replication when viral protein levels rise. The negative-sense RNA is used as a template to create a complimentary positive-sense strand of RNA, which is then used to synthesize negative-sense RNA for encapsidation</ins>. <ins style="font-weight: bold; text-decoration: none;">The newly-formed nucleocapsids </ins>have helical symmetry and are elongated.[6] <ins style="font-weight: bold; text-decoration: none;">Nucleocapsids bud from the </ins>host <ins style="font-weight: bold; text-decoration: none;">cell wall obtaining an envelope</ins>, and <ins style="font-weight: bold; text-decoration: none;">are released </ins>to find a new host <ins style="font-weight: bold; text-decoration: none;">cell. (source: [[Filoviridae]]) These Marburg virions measure about 80nm in diameter and optimally 790nm in length</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td></tr>
</table>
Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43369&oldid=prev
Adenjust: /* Ecology and Pathogenesis */
2009-04-22T09:33:17Z
<p><span dir="auto"><span class="autocomment">Ecology and Pathogenesis</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:33, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>The natural history and origin of Marburg viruses remain a total mystery. It appears to be transmitted zoonotically; with human infection occuring from animals. However, all attempts to trace human cases have failed to uncover the reservoir. Recent studies point to African fruit bats as a probable reservoir.[8] Whatever the origin, human to human contact is the main route of infection and transmission in human filoviral hemorrhagic fever outbreaks. However, Marburg virus has been transmitted to primates by aerosol in laboratory experiments.[1] The disease is primarily spread through bodily fluids such as blood, excrement, saliva, and vomit<del style="font-weight: bold; text-decoration: none;">. The hemorrhaging nature of Marburg infection is the main cause of prevalent transmission</del>. The incubation period is anywhere from five to ten days and early symptoms are often mild fever and headache. Symptoms usually last for 1-3 weeks until recovery or death of the infected host.[3] The fatality rate in many African <del style="font-weight: bold; text-decoration: none;">cases </del>has been as high as 90%.[7]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>The natural history and origin of Marburg viruses remain a total mystery. It appears to be transmitted zoonotically; with human infection occuring from animals. However, all attempts to trace human cases have failed to uncover the reservoir.<ins style="font-weight: bold; text-decoration: none;">[1] </ins>Recent studies point to African fruit bats as a probable reservoir.[8] Whatever the origin, human to human contact is the main route of infection and transmission in human filoviral hemorrhagic fever outbreaks. However, Marburg virus has been transmitted to primates by aerosol in laboratory experiments.[1] The disease is primarily spread through bodily fluids such as blood, excrement, saliva, and vomit. The incubation period is anywhere from five to ten days and early symptoms are often mild fever and headache<ins style="font-weight: bold; text-decoration: none;">. Very soon after the classic symptoms of hemorrhagic fever are exhibited. The hemorrhaging nature of Marburg is the main reason for its high transmission rate</ins>. Symptoms usually last for 1-3 weeks until recovery or death of the infected host.[3] The fatality rate in many African <ins style="font-weight: bold; text-decoration: none;">outbreaks </ins>has been as high as 90%.[7]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>
Adenjust
https://microbewiki.kenyon.edu/index.php?title=Marburgvirus&diff=43368&oldid=prev
Adenjust: /* Virion Structure and Life Cycle */
2009-04-22T09:28:24Z
<p><span dir="auto"><span class="autocomment">Virion Structure and Life Cycle</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:28, 22 April 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Virion Structure and Life Cycle==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. The genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane, two matrix proteins, and the nucleocapsid proteins.[9] Marburg virions measure about 80nm in diameter and optimally 790nm in length<del style="font-weight: bold; text-decoration: none;">. Surface projections are spaced widely apart and are embedded in the GP</del>. Nucleocapsids have helical symmetry and are elongated.[6] As true of any virus, Marburg cannot survive without a host. During replication, newly copied virions accumulate rapidly in densely packed clusters and eventually burst out of the cell to find a new host.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Viruses are inherently dependent on a hosts machinery to replicate their genetic information; their prime directive is to produce as many copies of themselves as possible. The genomic RNA is transcribed into monocistronic mRNA species encoding seven structural proteins: a single surface protein(GP) inserted in the viral membrane <ins style="font-weight: bold; text-decoration: none;">with widely spaced surface projections for host attachment</ins>, two matrix proteins, and the nucleocapsid proteins.[9] Marburg virions measure about 80nm in diameter and optimally 790nm in length. Nucleocapsids have helical symmetry and are elongated.[6] As true of any virus, Marburg cannot survive without a host. During replication, newly copied virions accumulate rapidly in densely packed clusters and eventually burst out of the cell to find a new host.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology and Pathogenesis==</div></td></tr>
</table>
Adenjust