Mouse Mammary Tumor Virus: Difference between revisions
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==Reproductive Cycle of MMTV== | ==Reproductive Cycle of MMTV== | ||
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MMTV can be transferred through either an endogenous (vertical) or exogenous (horizontal) pathway. | |||
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The endogenous pathway occurs when the virus is transferred from mother to progeny as a provirus, inserted in the host DNA. In a typical strain there are as many as 14 proviruses, most of which are no longer functional. The proviruses are transmitted in mendelian fashion. | |||
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The exogenous pathway occurs through transfer of the viral particles, from mother to progeny, in the milk. Other body fluids might also contains low levels of MMTV particles, but milk remains the main route of exogenous transfer of the virions. | |||
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==Viral Ecology & Pathology== | ==Viral Ecology & Pathology== | ||
Revision as of 18:39, 16 September 2008
A Viral Biorealm page on the family Mouse Mammary Tumor Virus
Baltimore Classification
Group VI. RNA Reverse Transcribing Viruses (Retroviruses)
Higher order categories
Order: Unassigned
Family: Retroviridae
Subfamily: Orthoretrovirinae
Genus: Betaretrovirus
Description and Significance
Mouse Mammary Tumor Virus (MMTV)was reported for the first time in 1933 by the Jackson Memorial Laboratory. It was initially identified by studying inbred mouse strains characterized by a high incidence of mammary tumor.
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Genome Structure
Genome structure
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Virion Structure of MMTV
The MMTV virion is a B-type particle containing a genomic RNA dimer, encapsidated by NC proteins in the form of a helical nucleoprotein (RNP). Surrounding the genomic material is an apparently icosahedral capsid, formed by CA proteins. The capsid is bound to the envelope by the matrix protein MA. Finally, the viral envelope is characterized by several spikes, composed of a transmembrane protein and a surface protein [enc virology].
Reproductive Cycle of MMTV
MMTV can be transferred through either an endogenous (vertical) or exogenous (horizontal) pathway.
The endogenous pathway occurs when the virus is transferred from mother to progeny as a provirus, inserted in the host DNA. In a typical strain there are as many as 14 proviruses, most of which are no longer functional. The proviruses are transmitted in mendelian fashion.
The exogenous pathway occurs through transfer of the viral particles, from mother to progeny, in the milk. Other body fluids might also contains low levels of MMTV particles, but milk remains the main route of exogenous transfer of the virions.
Viral Ecology & Pathology
pathology.
cancer
info
References
references Page authored for BIOL 375 Virology, September 2008
