Mycobacterium leprae

From MicrobeWiki, the student-edited microbiology resource

A Microbial Biorealm page on the genus Mycobacterium leprae

Classification

Higher order taxa

Bacteria; Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae ; Mycobacterium [Others may be used. Use NCBI link to find]

Species

NCBI: Taxonomy

Mycobacterium leprae

Description and significance

Mycobacterium leprae is responsible for leprosy or Hansen's disease. Cases of leprosy have been recorded as early as 600 B.C. In 2004, The World Health Organization reported that there were 407,791 new cases of leprosy. Leprosy is a serious world issue, in Brazil, India, Democratic of Congo, Tanzania, Nepal, Mozambique, Madagascar, Angola and the Central African Republic leprosy is a major problem. Mycobacterium leprae is an intracellular bacterium, infecting nerve, skin and mucosal cells. In laboratory environments, Mycobacterium leprae is cultured on the feet of mice or on nine banded armadillos due to the inability to culture in vitro.

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

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Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

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References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Edited by student of Rachel Larsen and Kit Pogliano