Mycobacterium leprae -- Leprosy: Difference between revisions

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==Pathogenesis==
==Pathogenesis==
===Transmission===
===Transmission===
Although much about the transmission of <i>Mycobacterium leprae</i> is unknown, prolonged contact with an infected person increases an individual's chance of becoming infected. Armadillos can harbor the bacteria, but are not seen as a threat to human contraction of the disease. In addition, insects could be possible carriers of <i>Mycobacterium leprae</i> but this is unclear In humans, the bacteria is thought to be passed through skin and nasal mucosa (WHO). One study has demonstrated that large numbers of the bacteria can be found on the skin of infected persons, providing a possible means of transmission (Job). <i>Mycobacterium leprae</i> could also be passed through nasal mucosa like the closely related <Mycobacterium tuberculosis</i> (Nature).
Although much about the transmission of <i>Mycobacterium leprae</i> is unknown, prolonged contact with an infected person increases an individual's chance of becoming infected. Armadillos can harbor the bacteria, but are not seen as a threat to human contraction of the disease. In addition, insects could be possible carriers of <i>Mycobacterium leprae</i> but this is unclear In humans, the bacteria is thought to be passed through skin and nasal mucosa (WHO). One study has demonstrated that large numbers of the bacteria can be found on the skin of infected persons, providing a possible means of transmission (Job). <i>Mycobacterium leprae</i> could also be passed through nasal mucosa like the closely related <i>Mycobacterium tuberculosis</i> (Nature).


===Infectious dose, incubation, and colonization===
===Infectious dose, incubation, and colonization===

Revision as of 20:53, 23 July 2013

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Pathogenic Microbiology in Italy [1]
"Mycobacterium leprae" globi in patient. From: Escholarship.org [2]
Woman with leprosy. From: Leprosymission.org [3]

Etiology/Bacteriology

Taxonomy

| Domain = Bacteria | Phylum = Actinobacteria | Class = Actinobacteridae | Order = Actinomycetales | Suborder = Corynebacterineae | Family = Mycobacteriaceae | Genus = Mycobacterium | Species = M. leprae |

NCBI: Taxonomy Genome: Mycobacterium leprae

Description

Pathogenesis

Transmission

Although much about the transmission of Mycobacterium leprae is unknown, prolonged contact with an infected person increases an individual's chance of becoming infected. Armadillos can harbor the bacteria, but are not seen as a threat to human contraction of the disease. In addition, insects could be possible carriers of Mycobacterium leprae but this is unclear In humans, the bacteria is thought to be passed through skin and nasal mucosa (WHO). One study has demonstrated that large numbers of the bacteria can be found on the skin of infected persons, providing a possible means of transmission (Job). Mycobacterium leprae could also be passed through nasal mucosa like the closely related Mycobacterium tuberculosis (Nature).

Infectious dose, incubation, and colonization

Epidemiology

Map of new leprosy cases annually (2010) From: Leprosymission.org [4]

Virulence factors

Waxy exterior

Iron utilization

Macrophage invasion

Schwann cell invasion

Drug resistance

Clinical features

Clinical manifestations of "Mycobacterium leprae" infection. From: Bio.davidson.edu [5]

Classification

Type 1

Type 2

Lucio Phenomenon

Diagnosis

Treatment

Before and after Multidrug Therapy (MDT) From: Stlukesleprosyhospital.org [6]

Prevention

Vaccination

Eradication attempts

Immune Response

Protective immunity and susceptibility

Host defense

Bacterial evasion

References

1 Conway, Tyrrell. “Genus conway”. “Microbe Wiki” 2013. Volume 1. p. 1-2.

Created by Gracen Conway, student of Tyrrell Conway at the University of Oklahoma.