Natural Killer Cell

Overview

Natural killer cells (NK cells) under light microscopy (A) and electron microscopy (B). In Characterization of a Novel Human Natural Killer-Cell Line (NK-YS) Established From Natural Killer Cell Lymphoma/Leukemia Associated With Epstein-Barr Virus Infection (Tsuchiyama J. et al. 1998). Link:https://ashpublications.org/blood/article/92/4/1374/247309/Characterization-of-a-Novel-Human-Natural-Killer

Natural killer cells (NK cells) are a type of granular cytotoxic lymphocytes that are non-adherent and non-phagocytic. NK cells were originally defined as a subset of lymphocytes that have natural cytotoxic activity against certain types of tumorous cells and endogenous type-C viruses in mice. Natural cytotoxicity refers to the fact that they can rapidly cause tumor cells’ lyses in the absence of any previous stimulation [1,2]. They were first named in an article in 1976 [3] and later categorized as part of the innate immune system due to their morphology, origin (bone marrow), and lack of antigen-specific receptors (such as those on T and B-cells’ surfaces) and their respective genes. [4,5]

Colony of Marburg virus. Transmission electron microscope image taken by Dr. Tom Geisbert

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Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Section 1 Genetics

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Section 2 Microbiome

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Conclusion

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References

Edited by [Minh Pham], student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2019, Kenyon College.