Difference between revisions of "Orthoreovirus"

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(Reproductive Cycle of an Orthoreovirus in a Host Cell)
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[http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/ ICTV dB Descriptions]
[http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/ ICTV dB Descriptions]
[http://www-micro.msb.le.ac.uk/3035/Reoviruses.html Microbiology@Leicester: Reoviruses]

Revision as of 14:21, 29 June 2006

Orthoreovirus; From ICTV dB Descriptions

Baltimore Classification

Higher order taxa

Virus; Reoviridae (Family); Orthoreovirus.


Avian Orthoreovirus, Mammalian Orthoreovirus (examples)

Description and Significance

The orthoreovirus infects invertebrates, plants and vertebrates.

Genome Structure

The genome of orthoreovirus is monomeric, segmented and consists of ten segments of linear double-stranded RNA. The complete genome is 23700 nucleotides long. The L1 is sequenced but only an estimate is available. The sequence is 3800-3900 nucleotides long. L2 is sequenced and the complete sequence is 3800-3900 nucleotides long. L3 is sequenced too but only an estimate is given and the complete sequence is 3800-3900 nucleotides long as well. M1 has been fully sequenced and the complete sequence is 2200-2300 nucleotides long. M2 has been sequenced as well and is a long as M1 but only an estimate of the sequence is presented. S2 and S3 are sequenced and are 1200-1400 nucleotides long but only an estimate is presented. S4 has also been completely sequenced and is 1200-1400 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap. On the positive strand of each duplex, the negative strands have a phosphorylated terminus and the cap sequence type is m7G5ppp5'GmpNp. The multipartite genome is found in one type of particle only. Each virion contains a single copy of the genome but it may be a full lenght copy or shorter copies. (source: ICTV dB Descriptions)

Virion Structure of an Orthoreovirus

The virions of an orthoreovirus consist of a capsid, a core and a nucleoprotein complex. The virus capsid is not envelpped, isometric with icosahedral symmetry and has a diameter of 80-82 nm. The capsid shells of virions are composed of two layers. All the shells are usually present but sometimes the outer shell is lost during preparation. The capsids appear round and the surface structure reveals a regular pattern with distinctive features. The capsomer arrangement is clearly visible and surface projections are not present. The inner capsids are the core and have a diametere of 60 nm. The core is spherical and consists of dsRNA genome with a diameter of 49 nm. The end of the fibers protrude almost through to the capsid surface. (source: ICTV dB Descriptions)

Reproductive Cycle of an Orthoreovirus in a Host Cell

Viral Ecology & Pathology

The gastrointestinal and upper respiratory tracts are involved in most of the human orthoreovirus infections. The infections are asymptomic but occasionally produce mild febrile illness, or very rarely, serious complications.


ICTV dB Descriptions