Penicillium marneffei

A Microbial Biorealm page on the genus Penicillium marneffei

Classification

Higher order taxa

Domain: Fungi

Phylum: Ascomycota

Class: Eurotiomycetes

Order: Eurotiales

family: Trichocomaceae

genus: Penicillium

species: marneffei

Species

NCBI: Taxonomy

Penicillium marneffei

Description and significance

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated. Include a picture or two (with sources) if you can find them.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.

Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

1. Vanittanakom N, Cooper CR Jr, Fisher MC, Sirisanthana T. “Penicillium marneffei infection and and recent advances in the epidemiology and molecular biology aspect.” Clinical Microbiology Reviews (2006) -2006 January; 19(1): 95–110. - http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16418525

2. Boyce KJ, Hynes MJ, Andrianopoulos A. "The Ras and Rho GTPases genetically interact to co-ordinately regulate cell polarity during development in Penicillium marneffei." Molecular Microbiology (2005) - Volume 55 Issue 5 Page 1487-1501, March 2005 - http://www.blackwell-synergy.com/coi/abs/10.1111/j.1365-2958.2005.04485.x

3. Woo PC, Zhen H, Cai JJ, Yu J, Lau SK, Wang J, Teng JL, Wong SS, Tse RH, Chen R, Yang H, Liu B, Yuen KY. "The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to molds than yeasts." FEBS Letters (2003) - Volume 555, Issue 3, 18 December 2003, Pages 469-477 - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-4B22RX3-3&_user=10&_coverDate=12%2F18%2F2003&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=bc1887cf249b2ffde64a86d69b05628d

4. Lasker BA. "Nucleotide sequence-based analysis for determining the molecular epidemiology of Penicillium marneffei." Journal of Clinical Microbiology (2006) - September 2006, pg. 3145-3153, Vol. 44, No. 9- http://jcm.asm.org/cgi/content/full/44/9/3145?view=long&pmid=16954240

5. Lasker BA, Ran Y. "Analysis of polymorphic microsatellite markers for typing Penicillium marneffei isolates." Journal of Clinical Microbiology (2004) - April 2004, pg. 1483-1490, Vol. 42, no. 4 - http://jcm.asm.org/cgi/content/full/42/4/1483?view=long&pmid=1570993

6. Lim D, Lee YS, Chang AR. "Rapid Diagnosis of Penicillium marneffei infection by fine needle aspiration cytology." Journal of Clinical Pathology (2006) 59:443-444 - http:jcp.bmj.com/cgi/content/full/59/4/443

7. Cánovas D, Andrianopoulos A. "Developmental Regulation of the glyoxylate cycle in the human pathogen Penicillium marneffei." Molecular microbiology (2006) -Volume 62 Issue 6 Page 1725-1738, December 2006 - http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2958.2006.05477.x

8. Liu H, Xi L, Zhang J, Li X, Liu X, Lu C, Sun J. "Identifying differentially expressed genes in the dimorphic fungus Penicillium marneffei by suppression subtraction hybridization." FEMS Microbiology Letters (2007) -Volume 270 Issue 1 Page 97-103, May 2007 -http://www.blackwell-synergy.com/doi/abs/10.1111/j.1574-6968.2007.00652.x

9. Yuen KY, Pascal G, Wong SS, Glaser P, Woo PC, Kunst F, Cai JJ, Cheung EY, Medigue C, Danchin A. "Exploring the Penicillium marneffei genome." Archives of Microbiology (2003) volume 179, Number 5 / May, 2003 - http://www.springerlink.com/content/x9q965haa71c7c9v/

10. Prariyachatigul C, Chaiprasert A, Geenkajorn K, Kappe R, Chuchottaworn C, Termsetjaroen S, Srimuang S. "Development and evaluation of a one-tube seminested PCR assay for the detection and identification of Penicillium marneffei." Mycoses (2003) Volume 46 Issue 11-12, pg. 447-454, December 2003 - http://www.blackwell-synergy.com/doi/abs/10.1046/j.0933-7407.2003.00939.x

11. Supparatpinyo K, Schlamm H. "Voriconazole as Therapy for Systemic Penicillium marneffei Infections in AIDS patients." Tropical Medicine and Hygiene (2007) 77(2), pg. 350-353 - http://www.ajtmh.org/cgi/content/full/77/2/350

12. Thirach S, Cooper Jr. C, Vanittanakom P, Vanittanakom N. "The Copper, Zinc Superoxide Dismutase gene of Penicillium marneffei: Cloning, characterization, and differential expression during phase transition and macrophage infection." Medical Mycology (2007) Volume 45, issue 5 August 2007, pg. 409-417 - http://www.informaworld.com/smpp/section?content=10.1080/13693780701381271

13. Penicillium marneffei, genus NCBI reference: http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=37727&lvl=3&p=mapview&p=has_linkout&p=blast_url&p=genome_blast&lin=f&keep=1&srchmode=1&unlock

Edited by Tiffanie Chan, student of Rachel Larsen