Difference between revisions of "Plasmodium vivax"

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[c] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198891/ Am J Trop Med Hyg. 2016 Dec 28; 95(6 Suppl): 15–34. doi: 10.4269/ajtmh.16-0141
[c] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198891/ Am J Trop Med Hyg. 2016 Dec 28; 95(6 Suppl): 15–34. doi: 10.4269/ajtmh.16-0141]

Revision as of 23:17, 29 April 2020

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Figure 1. Plasmodium Vivax Trophozoite

Domain: Eukaryote

Phylum: Apicomplexa

Class: Aconoidasida

Order: Haemosporida

family: Plasmodiidae


NCBI: Taxonomy

Plasmodium vivax

Description and Significance

Describe the appearance, habitat, etc. of the organism, and why you think it is important.

stages of P.vivax development


P. vivax are parasites found inhabiting the liver and blood at various stages of development and shape. Starting as rings within red blood cells, then trophozoites as they develop within the red blood cells. Next, they form round gametocytes filling the red blood cells and schizonts which are elongated and wormlike, further filling out the red blood cells. Red blood cells infected by P. vivax cause swelling of the cell, increasing the size by approximately 1.5 times the size.


P. vivax is found within South America and Asia, along with smaller amounts found within the horn of africa and Madagascar. P. vivax is the most widespread of human malaria, with farther reaches than the temperate limited Plasmodium falciparum more commonly known, enabled by the parasite forming a dormant stage within the human liver, enabling safe storage for the parasite during mosquito-free cold seasons.[b]


P. vivax has great signifigance due to the formation of hypnozoites within livers of infected human hosts. This hypnozoite stage leads to a "hybernation" where P. vivax remains dormant until unknown factors trigger growth, and relapses of symptoms weeks, months, or years later, remaining infectious throughout [c]. This continual infectious period makes treatment, eradication, and control of the parasite difficult.[d]

Genome Structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?

Cell Structure, Metabolism and Life Cycle


Life Cycle / Cell Structure

Plasmodium genus eukaryotes form a typical lifecycle characterized by infection from insect host to vertebrate host. P. vivax first enters a vertebrate host through injection by Anopheles mosquitoes (female only) where P. vivax makes their way from the blood to the liver, entering hepatic cells and undergoing replication before exiting to infect erythrocytes and forming hypnozoites and merozoites, some differing to form gametocytes to be picked up by other mosquitoes to continue the cycle.

Human Infection

Liver Stage
Erythrocytic Stage

Mosquito Infection


Ecology and Pathogenesis

Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.




[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

[a] Vogel G. The forgotten malaria. Science. 2013;342(6159):684‐687. doi:10.1126/science.342.6159.684


[c] Am J Trop Med Hyg. 2016 Dec 28; 95(6 Suppl): 15–34. doi: 10.4269/ajtmh.16-0141



Page authored by Jonathan Ward, student of Prof. Jay Lennon at IndianaUniversity.