Propionibacterium acnes is a commensal, non-sporulating bacilliform (rod-shaped), gram-positive bacterium found in a variety of locations on the human body including the skin, mouth, urinary tract and areas of the large intestine. P. acnes is most commonly associated with its implicated role as the predominant cause of the common inflammatory skin condition acne vulgaris. It is primarily anaerobic and has an optimal growing temperature of 37°C.
Higher Order Taxa:
Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Propionibacterineae; Propionibacteriaceae; Propionibacterium
- Corynebacterium acnes
- Bacillus acnes
- Corynebacterium acnes (Gilchrist 1900 and Eberson 1918)
- Bacillus acnes (Gilchrist 1900)
The genome of P. acnes has been sequenced in its entirety and has been shown to consists of a single 2.56026 Mbp circular DNA plasmid containing 2351 putative genes coding for 2297 known protein products and constituing a 60% G-C (guanine-cytosine) content.
Cell Structure and Metabolism
Applications to Biotechnology
1. Allison, Clive et al. Dissimilatory Nitrate Reduction by Propionibacterium acnes. Applied and Environmental Microbiology. 1989. Vol. 55 (11): 2899-2903.
2. Brüggemann, Holger et al. The Complete Genome Sequence of Propionibacterium Acnes, a Commensal of Human Skin. Science. 2005. 305: p. 671-672.
3. Farrar, Mark D. et al. Genome Sequence and Analysis of a Propionibacterium acnes Bacteriophage, Journal of Bacteriology.2007. Vol. 189 (11) p. 4161–4167.
4. Higaki, Shuichi et al. Propionibacterium acnes Biotypes and Susceptibility to Minocycline and Keigai-rengyo-to. International Journal of Dermatology. 2004. 43: p. 103–107.
5. Ingham, Eileen The Immunology of Propionibacterium acnes and Acne. Current Opinion in Infectious Diseases. 1999. Vol. 12(3): p. 191-197.
6. Liavonchanka, Alena et al. Structure and Mechanism of the Propionibacterium acnes Polyunsaturated Fatty Acid Isomerase. PNAS. 2006. Vol. 103 (8): p. 2581.
7. Moore, W.E.C. et al. Validity of Propionibacterium acnes (Gilchrist) Douglas and Gunter Comb. Nov. Journal of Bacteriology. 1962. p. 870-874.
8. Oprica, Cristina et al. Clinical and Microbiological Comparisons of Isotretinoin vs. Tetracycline in Acne Vulgaris. Acta Derm Venereol. 2007. Vol. 87: p. 246–254.
9. Rosenberg, E. William Bacteriology of Acne. Annual Reviews. 1969. Vol. 20: p. 201-206.