Pseudomonas aeruginosa

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A Microbial Biorealm page on the genus Pseudomonas aeruginosa

Classification

Higher order taxa

Domain Bacteria
Phylum Proteobacteria
Class Gamma proteobacteria
Order Pseudomonadales
Family Pseudomonadaceae
Genus Pseudomonas
Species Group Pseudomonas aeruginosa group

Species

NCBI: Taxonomy

Genus species Pseudomonas aeruginosa

Description and significance

Describe the appearance, habitat, etc. of the organism, and why it is important enough to have its genome sequenced. Describe how and where it was isolated. Include a picture or two (with sources) if you can find them.

Genome structure

Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? Does it have any plasmids? Are they important to the organism's lifestyle?

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.

Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Pathology

How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

Enter summaries of the most recent research here--at least three required

References

1) Lederberg, Joshua et al. Pseudomonas. Encyclopedia of Microbiology. Second Edition. Volume 3. San Diego, 2000. p. 876-891.

2) Costerton, W., and Anwar, H. Pseudomonas aeruginosa: The Microbe and Pathogen. Pseudomonas aeruginosa Infections and Treatment. 1994. p.1-17.

3) Botzenhardt, K., and Doring, G. Ecology and epidemiology of Pseudomonas aeruginosa. Pseudomonas aeruginosa as an Opportunistic Pathogen. 1993. p. 1-7.

4) Fick, R. Pseudomonas aeruginosa—the Microbial Hyena and Its Role in Disease: An Introduciton. Pseudomonas aeruginosa: The Opportunist. 1993. p. 1-6. 5) National Center for Biotechnology Information site 6) Gilardi, G. Cultural and Biochemical Aspects for Identification of Glucose-Nonfermenting Gram-Negative Rods. Nonfermenting Gram-Negative Rods. 1985. p.17-24. 7) Wiehlmann, L., Wagner, G., Cramer*, N., Siebert, B., Gudowius, P., Morales, G., Ko, T., Delden, C., Weinel, C., Slickers, P., and Tu, B. “Population structure of Pseudomonas aeruginosa”. Preceedings of the National Academy of Sciences of the United States of America. 2007. Volume 104. p. 8101–8106.

8) Craig, W., and Ebert, S. Antimirobial Therapy in Pseudomonas aeruginosa Infections. Pseudomonas aeruginosa Infections and Treatment. 1994. p. 470-491.

9) Pseudomonas Genome Database

10) Stover, K., Pham, Q., Erwin, L., Mizoguchi, D., Warrener, P., Hickey, J., Brinkman, L., Hufnagle, O., Kowalid, D., M. Lagrou, R. L. Garber, L. Goltry, E. Tolentino, S. Westbrock-Wadman, Y. Yuan, L. L. Brody*, S. N. Coulter, Folger, R., Kas, A., Larbig, K., Lim², R., Smith², K., Spencer², D., Wong², K.,Wu², Z., Paulsenk, J., Reizer, Z., Saier, H., Hancock³, R., Lory, S., and Olson, V. “Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen”. Nature. 2000. Volume 406. p. 961-964.

11) P. aeruginosa PA14 Genomic Sequencing Project

12) Stanisich, V., and Richmond, M. Gene Transfer in the Genus Pseudomonas. Genetics and Biochemistry of Pseudomonas. 1975. p. 170-175.

13) Delden, C. Virulence Fators in Pseudomonas aeruginosa. Pseudomonas. 2004. p. 1-7.

14) Cox, C. Iron and the Virulence of Pseudomonas aeruginosa. Pseudomonas aeruginosa: The Opportunist. 1993. p. 41-45.

15) Rabaey, K., and Verstraete, W. “Microbial Fuel Cells: novel biotechnology for enegy generation”. TrendS in Biotechnology. 2005. Volume 23.

16) Rojo, F., and Dinamarca, A. Catabolite Repression and Physiological Control. Pseudomonas. 2004. p. 365-366.

17) Valls, M., Cases, I., and Lorenzo, V. Transcription Mediated by rpoN-Dependent Promoters. Pseudomonas. 2004. p. 398-302.

18) Center for Diseases Control and Prevention

19) Center for Biofilm Engineering

20) Brown, M., and Simith, A. Antimicrobial Agents and Biofilms. Medical Implications of Biofilms. 2003. p. 36-38.

21) Irvin, Randall. Attachment and Colonization of Pseudomonas aerugionsa: Role of the Surface Structures. Pseudomonas aeruginosa as an Opportunistic Pathogen. 1993. p. 19-36.

22) Lowbury, E. Biological Importance of Pseudomonas aeruginosa: Medical Aspects. Genetics and Biochemistry of Pseudomonas. 1975. p. 37-43.

23) Holden, M., and Williams, P. “Quorum Sensing”. Encyclopedia of Life Sciences. 2001. 24) Smiley, A., and Hassett, D. Pseudomonas aeruginosa Biofilm Infections in Cystic Fibrosis. Biofilms, Infection, and Antimicrobial Therapy. 2006. p. 155-158.

25) Pieper, D., Stadler-Fritzche, K., Scholomann, M., and Knackmuss, H. Metabolism of 2-Chloro-4-Methylphenoxyacetate by Alcaligenes eutrophus JMP 134: Implications for the Degradation of Chloro- and Methyl-Substituted Aromatics via ortho Cleavage. Pseudomonas Molecular Biology and Biotechnology. 1992. p. 268-272.

26) [http://aem.asm.org/cgi/reprint/63/10/4047?ck=nck Johnson, G., and Olsen, R. “Multiple Pathways for Toluene Degradation in Burkholderia sp. Strain JS150.” Applied and Environmental Microbiology. 1997. Volume 63. p. 4047-4052.]

27) The National Aeronautics and Space Administration

28) Filho, L,, Tateno, A., Martins, K., Chernishev, A., Garcia, D., Haug,M., Meisner, C., Rodrigues, C., and Do, G. “The Combination of PCR and Serology Increases the Diagnosis of Pseudomonas aeruginosa Colonization/Infection in Cystic Fibrosis.” Pediatric Pulmonology. 2007. Volume 42. p. 938–944.

29) [http://genomebiology.com/content/pdf/gb-2006-7-10-r90.pdf Lee, D., Urbach, J., Wu, G., Liberati, N., Feinbaum, R., Miyata, S., Diggins, L., He, J., Saucier, M., Déziel, E., Friedman, L., Li, L., Grills, G., Montgomery, K., Kucherlapati, R., Rahme, L., and Ausubel, F. “Genomic analysis reveals that Pseudomonas aeruginosa virulence is Combinatorial.” Genome Biology. 2007. Volume 7.]



Edited by Chelsea Dao, a student of Rachel Larsen