Sarcoptes scabiei: Difference between revisions

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==Diagnosis==
==Diagnosis==
Scabies is hard to diagnose clinically and current methods such as serology tests have less than 50% accuracy [[#Reference6]]]. New diagnostic testing which measures the specific IgE antibodies that are produced in response to the major scabies antigen Sar s 14.3 has proven to be very effective at detecting scabies. Specifically this antibody sensitivity test yields a 93.75 % diagnosis success rate.
Scabies is hard to diagnose clinically and current methods such as serology tests have less than 50% accuracy [[#References|[6]]]. New diagnostic testing which measures the specific IgE antibodies that are produced in response to the major scabies antigen Sar s 14.3 has proven to be very effective at detecting scabies. Specifically this antibody sensitivity test yields a 93.75 % diagnosis success rate. Most commonly scabies is diagnosed by rash appearance and distribution however this is simply a superficial form of diagnosis. Similarly an ink test may be used but is also regarded as a superficial form of diagnosis. An ink test is carried out by wiping ink on the affected area and removing the ink with an alcohol pad. If scabies burrows are present, then some of the ink will remain within the burrows. To confirm diagnosis, skin samples may be taken from the affected area and examined for presence of mites or their eggs.


==Treatment==
==Treatment==

Revision as of 21:02, 29 July 2014

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Microbiology in Italy[1]

Etiology/Bacteriology

Taxonomy

| Domain = Animalia | Phylum = Eumetazoa | Class = Arachnida | Order = Astigmata | Family = Sarcoptidae | Genus = [[Sarcoptes]] | species = [[Sarcoptes scabies]]

NCBI: Taxonomy Genome: []

Description

Pathogenesis

Transmission

Sarcoptes scabiei is transmitted via person to person contact. Usually prolonged contact is required for scabies to spread [1]. Consequently, household members and significant others are the significant mode of transmission. The most common source of infection in adults is from sexual partners. Scabies may be spread via inanimate objects such as clothing and bedding but the chances are significantly low because scabies do not survive for more than two-three days without human contact [1]. If the symptoms of scabies have become severe enough to cause crusted scabies, transmission via clothing and other articles increases significantly.

Infectious dose, incubation, and colonization

Sarcoptes scabiei is a parasite of the skin which lends to a low infectious dose because many times colonization only requires the transfer of one parasite. If the parasite transmitted is an adult female carrying fertilized eggs, colonization is almost always assured unless the parasite is washed off within a 30 minutes of the transfer period. Adult males hardly ever burrow accept to follow a female burrow path for mating purposes [2]. Before burrowing, Sarcoptes scabiei will crawl to bodily crevices such as the elbows, feet, ankles, hands, and genital area. The parasite will then burrow into host skin using its front legs and mouth to cut away the skin in a typical zig-zag pattern. As the female parasite burrows it will lay eggs along the way. An adult female will continue to lay 2-3 eggs a day for two months until it dies. The life cycle of Sarcoptes scabiei is separated into four stages. Initially, the eggs will hatch into larvae within three days of being laid. The larvae will feed off of host hair follicles until it molts into an eight-legged nymph [2] At this point, all nymphs are destined to be males. If nymph molts another time, it will become a female. The first round of molting takes lasts for 10 days. If a second molting event occurs, then another 7 days is required to complete the female formation. Consequently, the females will be much larger than their male counterparts because they have nearly double the time to scavenge nutrients before complete development. Mating only occurs once in the lifetime of each parasite because the females can carry the sperm for two months while continually fertilizing new eggs. Soon after the two month fertile period the female will die.

Epidemiology

Scabies epidemics have been reported for over 3,000 years in places throughout Asia [4]. Many factors are suggested to have affected the epidemiology of scabies such as changing social attitudes, population movements, and wars [5]. People worldwide are affected by scabies. The parasitic infection is spread across all social classes in all corners of the world. However, impoverished and crowded regions are more susceptible to infection. Specifically it has been noted that all scabies epidemics have stemmed from not only impoverished areas but areas with poor sanitation and water supply. Incidentally the two are usually linked. Each year around 300 million people are affected by scabies [3].

Virulence factors

Clinical features

The clinical symptoms of Sarcoptes scabiei include intensely itchy lesions that often lead to further deleterious infections. The initial rash that presents during scabies infestation takes 4 to 6 weeks to develop thus clinical features mimics those of many other dermatological diseases. It is thought that the delay of symptoms allows for the parasite to spread to other hosts before the transmitting host even realizes infection has occurred. The rash presents in many forms such that it may resemble hives, mosquito bites, or pimples [8]. Itching of the affected area tends to occur most commonly at night keeping the infected host awake. The more deleterious diseases that result from the secondary effects of scabies are caused when infection develops in the sores created by scratching the primary rashes. Once the mite infestation progresses into its severe form then thick crusts form on the skin. Each of these crusts may contain 100 to 1000 mites and eggs [7]. Infection is a prevalent possibility at such an advanced state of infestation.

Diagnosis

Scabies is hard to diagnose clinically and current methods such as serology tests have less than 50% accuracy [6]. New diagnostic testing which measures the specific IgE antibodies that are produced in response to the major scabies antigen Sar s 14.3 has proven to be very effective at detecting scabies. Specifically this antibody sensitivity test yields a 93.75 % diagnosis success rate. Most commonly scabies is diagnosed by rash appearance and distribution however this is simply a superficial form of diagnosis. Similarly an ink test may be used but is also regarded as a superficial form of diagnosis. An ink test is carried out by wiping ink on the affected area and removing the ink with an alcohol pad. If scabies burrows are present, then some of the ink will remain within the burrows. To confirm diagnosis, skin samples may be taken from the affected area and examined for presence of mites or their eggs.

Treatment

Prevention

Host Immune Response

References

1 CDC-Scabies-General Information-FAQ
2 Parasites in Humans: Sarcoptes scabiei-Scabies
3 WHO I Water Related Diseases
4 Stanford Web: Scabies
5 Green, Manford S. Epidemiology of Scabies. Epidemiological Reviews. 1989 11 (1): 126-150.
7 American Academy of Dermatology Scabies: Signs and Symptoms
8 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865595/ Walton, Shelley F. and Bart J. Currie. Problems in Diagnosing Scabies, a Global Disease in Human and Animal Populations. Clinical Microbiology Reviews. 2007 Apr: 20(2): 268-279.