Difference between revisions of "Talimogene Laherparepvec: A groundbreaking viral therapy for late stage melanoma"

From MicrobeWiki, the student-edited microbiology resource
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==Introduction==
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==Classification==
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<b> Baltimore classification: </b> dsDNA <br>
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<b> Family: </b> Herpesviridae <br>
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<b> Virion: </b> Enveloped <br>
 +
<b> Capsid symmetry: </b> Icosahedral <br>
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<b> Replication site: </b>Nucleus and cytoplasm <br>
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 +
==Overview of Talimogene Laherparepvev (T-VEC)==
  
 
[[ http://darwin.bio.uci.edu/~faculty/wagner/hsvimg02.jpg|thumb|300px|right|<b> Figure 1:</b>  <i> </i>  <i>  </i>   
 
[[ http://darwin.bio.uci.edu/~faculty/wagner/hsvimg02.jpg|thumb|300px|right|<b> Figure 1:</b>  <i> </i>  <i>  </i>   
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<br><b>Superscript:</b> Fe<sup>3+</sup>
 
<br><b>Superscript:</b> Fe<sup>3+</sup>
  
==Classification==
 
<b> Baltimore classification: </b> dsDNA <br>
 
<b> Family: </b> Herpesviridae <br>
 
<b> Virion: </b> Enveloped <br>
 
<b> Capsid symmetry: </b> Icosahedral <br>
 
<b> Replication site: </b>Nucleus and cytoplasm <br>
 
  
 
==Section 2==
 
==Section 2==

Revision as of 20:45, 2 April 2018

This is a curated page. Report corrections to Microbewiki.

Classification

Baltimore classification: dsDNA
Family: Herpesviridae
Virion: Enveloped
Capsid symmetry: Icosahedral
Replication site: Nucleus and cytoplasm

Overview of Talimogene Laherparepvev (T-VEC)

[[ http://darwin.bio.uci.edu/~faculty/wagner/hsvimg02.jpg%7Cthumb%7C300px%7Cright%7C Figure 1:



By Alex Fazioli

Talimogene Laherparepvec (T-VEC) is an engineered Herpes simplex virus type 1 designed to specifically target, reproduce, and lyse human tumor cells [1]. T-VEC also produces granulocyte macrophage colony-stimulating factor (GM-CSF) to improve the antitumor immune response within the human body upon the lysis of tumor cells [1]. T-VEC avoids infecting non-cancerous cells by having all copies of two key neurovirulence factor genes deleted RL1 and US12 [2]. The deletion of the US12 gene puts its promoter in close proximity to the US11 increasing its expression which has been shown to increase the ability of T-VEC to replicate within tumour cells [3].


Double brackets: [[
Filename: PHIL_1181_lores.jpg
Thumbnail status: |thumb|
Pixel size: |300px|
Placement on page: |right|
Legend/credit: Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the CDC.
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Other examples:
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Subscript: H2O
Superscript: Fe3+


Section 2

Include some current research, with at least one figure showing data.

Section 3

Include some current research, with at least one figure showing data.

Section 4

Conclusion

References


1. Andtbacka, R. H., Kaufman, H. L., Collichio, F., Amatruda, T., Senzer, N., Chesney, J., ... & Milhem, M. (2015). Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. Journal of clinical oncology, 33(25), 2780-2788.

2. Pol, J., Kroemer, G., & Galluzzi, L. (2016). First oncolytic virus approved for melanoma immunotherapy.

3. Liu, B. L., Robinson, M., Han, Z., Branston, R. H., English, C., Reay, P., & ... Coffin, R. S. (2003). ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Therapy, 10(4), 292.




Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2018, Kenyon College.