Difference between revisions of "Talk:Trypanosome Life Cycle"

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(Chinagozi Ugwu)
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==Chinagozi Ugwu==
 
==Chinagozi Ugwu==
  
This topic on the Trypanosome Life Cycle was very interesting and informative. You went into great detail about many things including the  
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Your topic on the Trypanosome Life Cycle was very interesting and informative.  
<>br a coat that is made of several different procyclin molecules. Before transmission to the human host, the trypanosome gathers the previously mentioned variable surface glycoprotein (VSG) coat. In fact, for almost all trypanosomes, infectivity from the insect vector to the mammal host correlates with the expression of a dense VSG coat.
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With regards to the time it takes for the different procyclic stage glycoprotein coats to arise in the cell membrane, typically a full coat will have grown in ~4 hours. For procyclic stage trypanosomes that had recently just infected a tsetse fly, the predominant version of procyclin that is found is GPEET-procyclin. Procyclic trypanosomes with large numbers of GPEET-procyclin and low levels of EP-procyclins are marked as “early stage Procyclic”. GPEET-procyclin coats typically last until about the 4th or 5th day of infection before higher concentrations of EP-procyclin molecules are found within them. During the late stage procyclic stage almost no GPEET-procyclins are found and EP1 and EP3-procyclins predominate the cellular glycoprotein coat. EP-2 procyclins are found in large numbers throughout every procyclic stage.

Revision as of 10:22, 21 April 2009

Overall, your microbe wiki page is extremely informative and you do a great job explaining some complicated topics, such as how the bacteria change the cell wall to avoid detection from the immune system and the different stages of the life cycle of the protist. There are no internal citations inside your page. To make sure that your sources receive proper credit for their work you should go through the paper and make your citations. There also is no discussion section. All three of your topics are explained in detail, but it would be nice to see a paragraph or two bringing all of your thoughts together at the end. You discuss T. brucei's life cycle almost exclusively. It would be interesting if you could bring in some information about other species in the Trypanosome genus. Great page though, it is evident that a lot of time and effort was put into researching Trypanosome life cycles.


Chinagozi Ugwu

Your topic on the Trypanosome Life Cycle was very interesting and informative.

With regards to the time it takes for the different procyclic stage glycoprotein coats to arise in the cell membrane, typically a full coat will have grown in ~4 hours. For procyclic stage trypanosomes that had recently just infected a tsetse fly, the predominant version of procyclin that is found is GPEET-procyclin. Procyclic trypanosomes with large numbers of GPEET-procyclin and low levels of EP-procyclins are marked as “early stage Procyclic”. GPEET-procyclin coats typically last until about the 4th or 5th day of infection before higher concentrations of EP-procyclin molecules are found within them. During the late stage procyclic stage almost no GPEET-procyclins are found and EP1 and EP3-procyclins predominate the cellular glycoprotein coat. EP-2 procyclins are found in large numbers throughout every procyclic stage.