https://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&feed=atom&action=historyYersinia pestis - Revision history2024-03-28T11:59:33ZRevision history for this page on the wikiMediaWiki 1.39.6https://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=123778&oldid=prevRmohan at 14:04, 13 May 20162016-05-13T14:04:48Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the ''Yersinia pestis'' organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for ''Y. pestis'' rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th century due to a nucleic acid-base confirmation.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the ''Yersinia pestis'' organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for ''Y. pestis'' rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th century due to a nucleic acid-base confirmation.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Many gram-negative bacteria (including E. tarda) use ferric uptake regulator (Fur) as an important transcriptional regulator. In E. tarda, Fur’s role is significant and multifaceted; Fur affects the growth, siderophore production, and acid tolerance of E. tarda, helps protect against oxidative stress and host serum, helps inhibit host immune response, and generally increases the overall virulence of the bacterium. </ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Y. pestis is well known as a flea-borne bacteria. However, it evolved from Y. pseudotuberculosis, which exhibited significant oral toxicity to flea vectors. This oral toxicity is caused by urease activity which has been silenced in Y. pestis, due to expression of the mutant ureD allele. Restoration of functional ureD rendered Y. pestis toxic to vectors, which may be invaluable knowledge for decreasing plague transmission. </ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>Rmohanhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=64926&oldid=prevBarichD at 15:08, 4 July 20112011-07-04T15:08:38Z<p></p>
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</table>BarichDhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=54917&oldid=prevBarichD at 19:18, 19 August 20102010-08-19T19:18:48Z<p></p>
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</table>BarichDhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=19709&oldid=prevGillenk: /* Cell structure and metabolism */2007-07-30T14:59:42Z<p><span dir="auto"><span class="autocomment">Cell structure and metabolism</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''Yersinia pestis'' is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)].</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''Yersinia pestis'' is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)].</div></td></tr>
</table>Gillenkhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=19391&oldid=prevGillenk at 17:53, 9 July 20072007-07-09T17:53:36Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of ''Yersinia pestis'' in Madagascar. The researchers reported that the ''Y. pestis'' strain in Madagascar before 1982 was of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 (5)].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of ''Yersinia pestis'' in Madagascar. The researchers reported that the ''Y. pestis'' strain in Madagascar before 1982 was of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 (5)].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the ''Yersinia pestis'' organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for ''Y. pestis'' rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th due to a nucleic acid-base confirmation.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the ''Yersinia pestis'' organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for ''Y. pestis'' rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th <ins style="font-weight: bold; text-decoration: none;">century </ins>due to a nucleic acid-base confirmation.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>Gillenkhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=19390&oldid=prevGillenk: edited KMG 7/9/072007-07-09T17:51:36Z<p>edited KMG 7/9/07</p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description and significance==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Description and significance==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis was discovered in Hong Kong in 1894 by a Swiss physician Alexandre Yersin, who was a student of the Pasteur school of thought. He linked Y. pestis to the bubonic plauge, an epidemic that ravaged Europe during the 1300s. The organism was isolated during a outbreak in Hong Kong, a new geographical region for the organism that has been seen in Europe and Africa.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>was discovered in Hong Kong in 1894 by a Swiss physician Alexandre Yersin, who was a student of the Pasteur school of thought. He linked <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>to the bubonic plauge, an epidemic that ravaged Europe during the 1300s. The organism was isolated during a outbreak in Hong Kong, a new geographical region for the organism that has been seen in Europe and Africa.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>It is very important to have the genome sequenced for Y. pestis because this organism is capable of causing very fatal diseases. Since scientists were able to sequence the genome, they now have information of how diseases caused by this pathogenic bacteria <del style="font-weight: bold; text-decoration: none;">are developed </del>and also the evolutionary history of the bacteria. Having the genome <del style="font-weight: bold; text-decoration: none;">sequenced </del>also means that they are able to determine other species that are related to <del style="font-weight: bold; text-decoration: none;">yersinia </del>pestis which can prevent future outbreaks.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>It is very important to have the genome sequenced for <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>because this organism is capable of causing very fatal diseases. Since scientists were able to sequence the genome, they now have information of how diseases caused by this pathogenic bacteria <ins style="font-weight: bold; text-decoration: none;">develop </ins>and also the evolutionary history of the bacteria. Having the genome <ins style="font-weight: bold; text-decoration: none;">sequence </ins>also means that they are able to determine other species that are related to <ins style="font-weight: bold; text-decoration: none;">''Yersinia </ins>pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>which can prevent future outbreaks.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome structure==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome structure==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis has three <del style="font-weight: bold; text-decoration: none;">sub species in which only </del>two have been sequenced, strain KIM and strain CO92. Each strain consists of one chromosome. Strain KIM consists of 4,600,755 base pairs and has a circular chromosome. "This strain is also related with the black plague. Strain CO92 has 4,653,728 base pairs and contains three plasmids (pMT1, pCD1 and pPCP1) of 96.2 kilobases (kb), 70.3 kb and 9.6 kb" [http://jb.asm.org/cgi/content/full/184/16/4601 (3)]. Strain KIM also carries these plasmids. These plasmids along with a pathogenicity island called HPI, create a protein that causes the pathogenicity of the organism. These factors are important for adhesion and injection of proteins into the host cell, invasion of the bacteria and binding of iron from red blood cells. The genome has many insertion sequences and many G-C base pair differences, which means frequent recombination. Many of the genes have been acquired from other bacteria and viruses. Strain CO92 also consists of 4,012 protein-coding genes and 150 pseudogenes [http://jb.asm.org/cgi/content/full/184/16/4601 (4)].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>has three <ins style="font-weight: bold; text-decoration: none;">subspecies and </ins>two have been sequenced, strain KIM and strain CO92. Each strain consists of one chromosome. Strain KIM consists of 4,600,755 base pairs and has a circular chromosome. "This strain is also related with the black plague. Strain CO92 has 4,653,728 base pairs and contains three plasmids (pMT1, pCD1 and pPCP1) of 96.2 kilobases (kb), 70.3 kb and 9.6 kb" [http://jb.asm.org/cgi/content/full/184/16/4601 (3)]. Strain KIM also carries these plasmids. These plasmids along with a pathogenicity island called HPI, create a protein that causes the pathogenicity of the organism. These factors are important for adhesion and injection of proteins into the host cell, invasion of the bacteria and binding of iron from red blood cells. The genome has many insertion sequences and many G-C base pair differences, which means frequent recombination. Many of the genes have been acquired from other bacteria and viruses. Strain CO92 also consists of 4,012 protein-coding genes and 150 pseudogenes [http://jb.asm.org/cgi/content/full/184/16/4601 (4)].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A recent study compared both these strains to show that one of these strains may have evolved from the other throughout the years.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A recent study compared both these strains to show that one of these strains may have evolved from the other throughout the years.</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l36">Line 36:</td>
<td colspan="2" class="diff-lineno">Line 36:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Ecology==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis interacts mainly with rodents such as rats and fleas. Through these carriers, Yersinia pestis is able to invade human cells and create diseases. Yersinia pestis are not rich in nuterients and can grow at temperatures ranging from about 26 <del style="font-weight: bold; text-decoration: none;">celcius </del> to 37 <del style="font-weight: bold; text-decoration: none;">elcius</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>interacts mainly with rodents such as rats and fleas. Through these carriers, <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>is able to invade human cells and create diseases. <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>are not rich in nuterients and can grow at temperatures ranging from about 26 <ins style="font-weight: bold; text-decoration: none;">Celcius </ins> to 37 <ins style="font-weight: bold; text-decoration: none;">Celcius</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathology==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis causes diseases through the bite of an infected rat or flea, but can also be transmitted by air. Fleas can become infected by taking the blood of other infected animals. Y. pestis grows in the midgut and eventually blocks the proventriculus, starving the flea for blood [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)]. The insects attempt to feed more often but end up giving back infected blood into the wound of the bite. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>causes diseases through the bite of an infected rat or flea, but can also be transmitted by air. Fleas can become infected by taking the blood of other infected animals. <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>grows in the midgut and eventually blocks the proventriculus, starving the flea for blood [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 (1)]. The insects attempt to feed more often but end up giving back infected blood into the wound of the bite. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Symptons include:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Symptons include:</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l56">Line 56:</td>
<td colspan="2" class="diff-lineno">Line 56:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Seizures</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Seizures</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against Y pestis infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 (1)] Killed Y. pestis vaccines induce some measure of host protection, although it is less effective.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against <ins style="font-weight: bold; text-decoration: none;">''</ins>Y pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 (1)] Killed <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>vaccines induce some measure of host protection, although it is less effective.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of symptoms.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of symptoms.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis can be killed with mild heat (55°C) and by treatment with 0.5 percent phenol for 15 minutes. It is susceptible to sulfadiazine, streptomycin, tetracycline, and chloramphenicol.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>can be killed with mild heat(55°C) and by treatment with 0.5 percent phenol for 15 minutes. It is susceptible to sulfadiazine, streptomycin, tetracycline, and chloramphenicol.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Application to Biotechnology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Application to Biotechnology==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Current Research==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Current Research==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Researchers <del style="font-weight: bold; text-decoration: none;">have </del>recently compared the strains of Yersinia pestis (strain C092 and KIM) and Yersinia pseudotuberculosis. This comparison would show how the pathogen could have evolved from each other within a few hundred years by acquiring new genes. These new genes can also inactivate some of the existing ones. In the end, ''Jargid et al'' determined that both strains could have diverged from a common ancestor thousands of years ago, however the lack of a reliable molecular clock, IS transposition and gene inactivation made it difficult to specifically determine the actual distance between both species [http://www.ias.ac.in/currsci/mar102005/691.pdf (6)]. They also concluded that gene inactivation could have lead to the different genes.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Researchers recently compared the strains of <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>(strain C092 and KIM) and <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pseudotuberculosis<ins style="font-weight: bold; text-decoration: none;">''</ins>. This comparison would show how the pathogen could have evolved from each other within a few hundred years by acquiring new genes. These new genes can also inactivate some of the existing ones. In the end, ''Jargid et al'' determined that both strains could have diverged from a common ancestor thousands of years ago, however the lack of a reliable molecular clock, IS transposition and gene inactivation made it difficult to specifically determine the actual distance between both species [http://www.ias.ac.in/currsci/mar102005/691.pdf (6)]. They also concluded that gene inactivation could have lead to the different genes.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of Yersinia pestis in Madagascar. The researchers reported that the Y. pestis strain in Madagascar before 1982 <del style="font-weight: bold; text-decoration: none;">were </del>of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 (5)].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>in Madagascar. The researchers reported that the <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>strain in Madagascar before 1982 <ins style="font-weight: bold; text-decoration: none;">was </ins>of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 (5)].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the Yersinia pestis organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who <del style="font-weight: bold; text-decoration: none;">have </del>died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for Y. pestis rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th due to a nucleic acid-base confirmation.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the <ins style="font-weight: bold; text-decoration: none;">''</ins>Yersinia pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. They used bodies of people who died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for <ins style="font-weight: bold; text-decoration: none;">''</ins>Y. pestis<ins style="font-weight: bold; text-decoration: none;">'' </ins>rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 (2)]. The researchers were able to confirm that the disease was present at the end of the 16th due to a nucleic acid-base confirmation.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>Gillenkhttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=14040&oldid=prevDhdang: /* Pathology */2007-06-04T08:15:02Z<p><span dir="auto"><span class="autocomment">Pathology</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:15, 4 June 2007</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l58">Line 58:</td>
<td colspan="2" class="diff-lineno">Line 58:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against Y pestis infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 (1)] Killed Y. pestis vaccines induce some measure of host protection, although it is less effective.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against Y pestis infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 (1)] Killed Y. pestis vaccines induce some measure of host protection, although it is less effective.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of <del style="font-weight: bold; text-decoration: none;">clinical </del>symptoms.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of symptoms.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis can be killed with mild heat (55°C) and by treatment with 0.5 percent phenol for 15 minutes. It is susceptible to sulfadiazine, streptomycin, tetracycline, and chloramphenicol.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis can be killed with mild heat (55°C) and by treatment with 0.5 percent phenol for 15 minutes. It is susceptible to sulfadiazine, streptomycin, tetracycline, and chloramphenicol.</div></td></tr>
</table>Dhdanghttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=14039&oldid=prevDhdang at 08:13, 4 June 20072007-06-04T08:13:41Z<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:13, 4 June 2007</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome structure==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Genome structure==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis has three sub species in which only two have been sequenced, strain KIM and strain CO92. Each strain consists of one chromosome. Strain KIM consists of 4,600,755 base pairs and has a circular chromosome. "This strain is also related with the black plague. Strain CO92 has 4,653,728 base pairs and contains three plasmids (pMT1, pCD1 and pPCP1) of 96.2 kilobases (kb), 70.3 kb and 9.6 kb" [http://jb.asm.org/cgi/content/full/184/16/4601 3]. Strain KIM also carries these plasmids. These plasmids along with a pathogenicity island called HPI, create a protein that causes the pathogenicity of the organism. These factors are important for adhesion and injection of proteins into the host cell, invasion of the bacteria and binding of iron from red blood cells. The genome has many insertion sequences and many G-C base pair differences, which means frequent recombination. Many of the genes have been acquired from other bacteria and viruses. Strain CO92 also consists of 4,012 protein-coding genes and 150 pseudogenes [http://jb.asm.org/cgi/content/full/184/16/4601 4].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis has three sub species in which only two have been sequenced, strain KIM and strain CO92. Each strain consists of one chromosome. Strain KIM consists of 4,600,755 base pairs and has a circular chromosome. "This strain is also related with the black plague. Strain CO92 has 4,653,728 base pairs and contains three plasmids (pMT1, pCD1 and pPCP1) of 96.2 kilobases (kb), 70.3 kb and 9.6 kb" [http://jb.asm.org/cgi/content/full/184/16/4601 <ins style="font-weight: bold; text-decoration: none;">(</ins>3<ins style="font-weight: bold; text-decoration: none;">)</ins>]. Strain KIM also carries these plasmids. These plasmids along with a pathogenicity island called HPI, create a protein that causes the pathogenicity of the organism. These factors are important for adhesion and injection of proteins into the host cell, invasion of the bacteria and binding of iron from red blood cells. The genome has many insertion sequences and many G-C base pair differences, which means frequent recombination. Many of the genes have been acquired from other bacteria and viruses. Strain CO92 also consists of 4,012 protein-coding genes and 150 pseudogenes [http://jb.asm.org/cgi/content/full/184/16/4601 <ins style="font-weight: bold; text-decoration: none;">(</ins>4<ins style="font-weight: bold; text-decoration: none;">)</ins>].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A recent study compared both these strains to show that one of these strains may have evolved from the other throughout the years.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>A recent study compared both these strains to show that one of these strains may have evolved from the other throughout the years.</div></td></tr>
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<td colspan="2" class="diff-lineno">Line 36:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 1].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 <ins style="font-weight: bold; text-decoration: none;">(</ins>1<ins style="font-weight: bold; text-decoration: none;">)</ins>].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l45">Line 45:</td>
<td colspan="2" class="diff-lineno">Line 45:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathology==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis causes diseases through the bite of an infected rat or flea, but can also be transmitted by air. Fleas can become infected by taking the blood of other infected animals. Y. pestis grows in the midgut and eventually blocks the proventriculus, starving the flea for blood [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 1]. The insects attempt to feed more often but end up giving back infected blood into the wound of the bite. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis causes diseases through the bite of an infected rat or flea, but can also be transmitted by air. Fleas can become infected by taking the blood of other infected animals. Y. pestis grows in the midgut and eventually blocks the proventriculus, starving the flea for blood [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 <ins style="font-weight: bold; text-decoration: none;">(</ins>1<ins style="font-weight: bold; text-decoration: none;">)</ins>]. The insects attempt to feed more often but end up giving back infected blood into the wound of the bite. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Symptons include:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Symptons include:</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l56">Line 56:</td>
<td colspan="2" class="diff-lineno">Line 56:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Seizures</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Seizures</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against Y pestis infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 1] Killed Y. pestis vaccines induce some measure of host protection, although it is less effective.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>"The major defense against Y pestis infection is the development of specific anti-envelope (F1) antibodies, which serve as opsonins for the virulent organisms, allowing their rapid phagocytosis and destruction while still within the initial infectious locus. The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. The host is immune to virulent rechallenge, the inoculum being eliminated as though the organisms were completely avirulent". [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1615 <ins style="font-weight: bold; text-decoration: none;">(</ins>1<ins style="font-weight: bold; text-decoration: none;">)</ins>] Killed Y. pestis vaccines induce some measure of host protection, although it is less effective.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of clinical symptoms.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis infections must be diagnosed quickly due to the high virulence of these organisms. Death from pneumonic plague can occur in as little as 24 hours after the first appearance of clinical symptoms.</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l68">Line 68:</td>
<td colspan="2" class="diff-lineno">Line 68:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Current Research==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Current Research==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Researchers have recently compared the strains of Yersinia pestis (strain C092 and KIM) and Yersinia pseudotuberculosis. This comparison would show how the pathogen could have evolved from each other within a few hundred years by acquiring new genes. These new genes can also inactivate some of the existing ones. In the end, ''Jargid et al'' determined that both strains could have diverged from a common ancestor thousands of years ago, however the lack of a reliable molecular clock, IS transposition and gene inactivation made it difficult to specifically determine the actual distance between both species [http://www.ias.ac.in/currsci/mar102005/691.pdf 6]. They also concluded that gene inactivation could have lead to the different genes.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Researchers have recently compared the strains of Yersinia pestis (strain C092 and KIM) and Yersinia pseudotuberculosis. This comparison would show how the pathogen could have evolved from each other within a few hundred years by acquiring new genes. These new genes can also inactivate some of the existing ones. In the end, ''Jargid et al'' determined that both strains could have diverged from a common ancestor thousands of years ago, however the lack of a reliable molecular clock, IS transposition and gene inactivation made it difficult to specifically determine the actual distance between both species [http://www.ias.ac.in/currsci/mar102005/691.pdf <ins style="font-weight: bold; text-decoration: none;">(</ins>6<ins style="font-weight: bold; text-decoration: none;">)</ins>]. They also concluded that gene inactivation could have lead to the different genes.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of Yersinia pestis in Madagascar. The researchers reported that the Y. pestis strain in Madagascar before 1982 were of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 5].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Another research showed a recent emergence of new variants of Yersinia pestis in Madagascar. The researchers reported that the Y. pestis strain in Madagascar before 1982 were of the ribotype B, but after 1982 strains with ribotypes R, Q and T were isolated on a high plateau on the island [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=230070 <ins style="font-weight: bold; text-decoration: none;">(</ins>5<ins style="font-weight: bold; text-decoration: none;">)</ins>].The researchers concluded that none of the strains studied from anywhere else in the world displayed these new ribotypes, that the new variants were not isolated on the seaport but on the high plateau and that the new strains were discovered after a recent plague surveillance was established.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the Yersinia pestis organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 2]. They used bodies of people who have died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for Y. pestis rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 2]. The researchers were able to confirm that the disease was present at the end of the 16th due to a nucleic acid-base confirmation.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Researchers have also detected the Yersinia pestis organism on a 400 year old set of teeth. They performed this research because the lack of suitable infected material has prevented direct discovery of the plague, thus making the idea of a black plague hypothetical. "The durability of dental pulp, together with its natural sterility, makes it a suitable material on which to conduct research" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 <ins style="font-weight: bold; text-decoration: none;">(</ins>2<ins style="font-weight: bold; text-decoration: none;">)</ins>]. They used bodies of people who have died from the plague in Europe. "PCRs incorporating ancient DNA extracts and primers specific for the human beta-globin gene demonstrated the absence of inhibitors in these preparations. The incorporation of primers specific for Y. pestis rpoB and the recognized virulence-associated pla repeatedly yielded products that had a nucleotide sequence indistinguishable from that of modern day isolates of the bacterium" [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9770538 <ins style="font-weight: bold; text-decoration: none;">(</ins>2<ins style="font-weight: bold; text-decoration: none;">)</ins>]. The researchers were able to confirm that the disease was present at the end of the 16th due to a nucleic acid-base confirmation.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>Dhdanghttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=13049&oldid=prevDhdang at 18:09, 3 June 20072007-06-03T18:09:26Z<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:09, 3 June 2007</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p>[[Image:Yp1.jpeg|thumb|Y.pestis]]</p></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile <ins style="font-weight: bold; text-decoration: none;">[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1609 1]</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.</div></td></tr>
</table>Dhdanghttps://microbewiki.kenyon.edu/index.php?title=Yersinia_pestis&diff=13048&oldid=prevDhdang at 18:08, 3 June 20072007-06-03T18:08:07Z<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Cell structure and metabolism==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Cell structure and metabolism==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Yp1.jpeg|thumb|Y.pestis]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><p></ins>[[Image:Yp1.jpeg|thumb|Y.pestis]]<ins style="font-weight: bold; text-decoration: none;"></p></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Yersinia pestis is a rod shaped gram-negative bacteria that can also have a spherical shape. It is also covered by a slime envelope that is heat labile. When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile.</div></td></tr>
</table>Dhdang