Vibrio

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A Microbial Biorealm page on the genus Vibrio

Contents

Classification

Higher order taxa:

Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae

Species:

Vibrio cholerae, V. fischeri, V. halioticoli

NCBI: Taxonomy Genome

Description and Significance

Vibrio bacteria are gram-negative and largely halophilic. However, a few species are nonhalophilic, depending on their sodium chloride requirements. Most species are also oxidase-positive. Most species are sensitive to acid pH, but tolerant of alkaline pH. As pathogenic organisms, the CDC estimates that there are 8,000 infections and 60 deaths each year that are the result of Vibrio infections.

Genome Structure

A great deal of research has been done on the genome structures of Vibrio species. The complete sequence of Vibrio cholerae plasmid pSIO1 was completed on February 23, 2005. Another Vibro cholerae plasmid, pTLC, was completed on July 7, 2003. Work on the genome structures of other species is progressing as well. The Vibro fishceri ES114 plasmid pES100 was completed on Febrary 14, 2005. A plasmid for Vibrio parahaemolyticus, pO3K6, was completed on June 29, 2000. Plasmids for Vibrio salmonicida LFI1238 (pVS43; May 23, 2005), and Vibrio vulnificus YJ016 (pYJ016; October 9, 2003), have also been completed.

Cell Structure and Metabolism

Euprymna scolopes, host of Vibrio fischeri. Photo by MJ McFall-Ngai.

Vibrio are rod-shaped, and can be straight or curved. They are motile organisms, using a single polar flagellum to travel. A few species, such as Vibrio fischeri, are bioluminescent. V. fischeri lose their flagellum once they become endosymbionts of the squids or fish they inhabit.

Vibrio can undergo both respiratory and fermentative metabolism. They are heterotrophic organisms, obtaining nutrients from their mutualistic, parasitic, or pathogenic relationships with other organisms.

Vibrio reproduce very simply, through asexual division.

Ecology

A: Skin lesions from a V. vulnificus infection. B: V. vulnificus bacteremia which developed after a fish bone injury. C: Bacteria isolated from the blood of the patient in photo B. Kenneth Todar, Todar's Online Textbook of Bacteriology.

Vibrio bacteria are most commonly found in marine or estuarine environments. However, they can be found in freshwater environmens as well. Vibrio are usually found in temperate or subtropic waters.

Many species form relationships with animals. Some are mutualistic, as is the case of many relationships between Vibrio and fish. V. fischeri is well known for these types of relationships. One of the most interesting features of the relationship between V. fischeri and its host (usually a squid) is that the host expells 90% of the V. fischeri each day. This is done to allow newly-hatched offspring to obtain the endosymbionts they need. Other relationship, however, are parasitic. The parasitic relationships typically affect fish, frogs, and eels.

Vibrio are often pathogens of humans. Several species of Vibrio, including V. cholerae, V. parahaemolyticus, and V. vulnificus, are known to cause seafood-borne illnesses such as septicaemia and wound infections. V. vulnificus is responsible for 95% of seafood-related deaths. While immunosuppressed individuals are most susceptible to Vibrio infections, these bacteria are capable of harming anyone. One of the symptoms of septicaemia is severe secondary lesions in the extremities. However, these cases are gender-specific, found routinely in males over 50. This is because estrogen protexted against the V. vulnificus endotoxin.

Another major disease caused by Vibrio species is cholera, which occurs when V. cholerae colonizes the small intestine and releases enterotoxins. Many antibiotic medications are inneffective in treating cholera. Thanks to improved sewage and water treatment, there is a low occurrence of V. cholerae in the United States. Over 90% of the choerla cases occurring in the U.S. are the result of travel to a country where this bacterium is prevalent. Recurring infections of cholera are rare. Attempts at creating a cholera vaccine have had only limited success. Humans are the only natural host of V. cholerae.

Some species have multiple strains, which have different levels of pathogenicity. For example, V. vulnificus has two groups. The first is pathogenic only to humans, while the second is pathogenic to eels and occasionally to humans. Each strain produces the same type of toxin, but the individual toxins are different.

References

Dennis Kunkel Microscopy, Inc.

Fix, Douglas F. "Vibrio." Accessed 8 July 2005.

Gopal, S, SK Otta, I Karunasagar, M Nishibuchi, and I Karunasagar. "The occurrence of Vibrio species in tropical shrimp culture environments; implications for food safety." International Journal of Food Microbiology. 2005 Jul 15;102(2):151-9.

Graf, J. "The Light-Organ Symbiosis of Vibrio fischeri and the Hawaiian Squid, Euprymna scolopes." February 2005. Accessed 8 July 2005.

Ho, Hoi. "Vibrio infections." eMedicine. 22 May 2005. Accessed 8 July 2005.

Oliver, JD. "Wound infections caused by Vibrio vulnificus and other marine bacteria." Epidemiology and infection. 2005 Jun;133(3):383-91.

Sarkar, M, S Das, A Bandyopadhaya, K Ray, and K Chaudhuri. "Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis." FEBS letters. 2005 Jun 20;579(16):3449-60.

Senoh, Mistutoshi, Shin-Ichi Miyoshi, Keinosuke Okamoto, Belen Fouz, Carmen Amaro, and Sumio Shinoda. "The Cytotoxin-Hemolysin Genes of Human and Eel Pathogenic Vibrio vulificus Strains: Comparison of Nucelotide Sequences and Application to the Genetic Grouping. Microbiology and immunology. 2005;49(6):513-9.

Todar, Kenneth. Todar's Online Textbook of Bacteriology. 2005. Accessed 8 July 2005.

Vibrio fischeri Genome Project. 19 September 2002. Accessed 8 July 2005.

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