File:BrainNF.jpeg

Summary

Figure 3Light microscopy histopathology of (B6C3)F1 mice inoculated intranasally with Naegleria fowleri. (a, b) Whole-brain sagital sections. (a) Uninfected mouse. (b) Infected mouse at 10 days postnasal instillation with trophozoites. Note the massive neuropathology (arrow) in the olfactory area and frontal lobe of the brain. (c) A focal lesion (arrow) in the striatum (st) of a mouse at 4 days postintranasal instillation with trophozoites. (d) Extensive accumulation of mononuclear and polymorphonuclear cells in striatum of mouse at 7 days postintranasal instillation with trophozoites. Note the numerous trophozoites admixed with the mononuclear and polymorphonuclear cells. All sections were stained with hematoxylin and eosin. The bars designate 2 mm for (a) and (b) and 10 µm for (b) and (c). am, amygdala; cb, cerebellum; ctx, cerebral cortex; gp, globus pallidus; hi, hippocampus; ob, olfactory bulb; th, thalamus; st, striatum.