Diphtheria: Difference between revisions
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[[Category:Pages edited by students of Tyrrell Conway at the University of Oklahoma]][[Image:OULOGOBIANCO.JPEG|thumb|230px|left|University of Oklahoma Study Abroad Microbiology in Arezzo, Italy[http://cas.ou.edu/study-abroad/]]] | [[Category:Pages edited by students of Tyrrell Conway at the University of Oklahoma]][[Image:OULOGOBIANCO.JPEG|thumb|230px|left|University of Oklahoma Study Abroad Microbiology in Arezzo, Italy[http://cas.ou.edu/study-abroad/]]] | ||
[[Image:cdiphtheriametachromatic.jpg|thumb|400px|right|''C. diphtheriae'' bacteria, in green, showing metachromatic granules on the ends of the cell. From: http://textbookofbacteriology.net/diphtheria.html]] | |||
==Etiology/Bacteriology== | ==Etiology/Bacteriology== | ||
Revision as of 06:58, 22 July 2015
University of Oklahoma Study Abroad Microbiology in Arezzo, Italy[1]
File:Cdiphtheriametachromatic.jpg
C. diphtheriae bacteria, in green, showing metachromatic granules on the ends of the cell. From: http://textbookofbacteriology.net/diphtheria.html
Etiology/Bacteriology
Taxonomy
| Domain = Bacteria | Phylum = Actinobacteria | Class = Actinobacteria | Order = Actinomycetales | Family = Corynebacteriaceae | Genus = Corynebacterium | Species = Diphtheriae
Description
C. diphtheriae infections are the causal agent of diphtheria. Four subspecies are recognized: C. d. mitis, C. d. intermedius, C. d. gravis, and C. d. belfanti. C. diphtheria is known to produce diphtheria toxins. C. diphtheria are Gram-positive, rod-shaped (and highly pleomorphic), aerobic, and nonmotile.
Pathogenesis
Virulence factors
Diphtheria toxin
Diphtheria toxin is an exotoxin that prevents protein synthesis through inactivation of eEF2 (eukaryotic elongation factor 2). This is done by ADP-ribosylating the amino acid diphthamide, inhibiting RNA translation.
