Bordetella pertussis: Difference between revisions
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==Genome structure== | ==Genome structure== | ||
''Bordetella pertussis'' strain Tohama I has its complete genome sequenced. The genome consists of 1 circular chromosome with 4,086,189 nucleotides (3867 genes). Approximately 67% of the genome is GC rich and its coding density is 82% (1056 bp/gene). [10] | |||
The IncP-1 beta plasmid pBP136 from ''Bordetella pertussis'' is also sequenced. It contains 41,268 bp nucleotides and carries 46 ORFs. Two of the ORFs have similar genes with unknown function to a plant pathogen called “Xylella fastidiosa”. pBP136 plasmid do not contain any accessory genes that code for antibiotics, mercury resistance, or xenobiotic degradation. Its role in the bacteria is unclear and is still under investigation. [9] | |||
==Cell structure and metabolism== | ==Cell structure and metabolism== | ||
Revision as of 09:58, 4 June 2007
A Microbial Biorealm page on the genus Bordetella pertussis
Classification
Higher order taxa
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
Species: B. pertussis
Species
Bordetella pertussis
Other Names: “Haemophilus pertussis” (Pribram 1933) “Bacterium tussis-convulsivae” (Lehmann and Neumann 1927) "Hemophilus pertussis" (Bergey et al. 1923), and "Microbe de la coqueluche" Bordet and Gengou 1906. [10]
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NCBI: Taxonomy |
Description and significance
Bordetella pertussis is a small, Gram-negative, coccoid bacterium about the size of 0.8 µm by 0.4 µm. It is an encapsulated immotile aerobe that does not make spores. Bordetella pertussis produces a number of virulence factors, including pertussis toxin, adenylate cyclase toxin, filamentous hemagglutinin, and hemolysin. It cannot survive in the environment; it must reside in a host either in small groups or singly. It grows at an optimal temperature of 35-37ºC. [1]
Bordetella pertussis is a strict human pathogen that is the causative agent of pertussis (whooping cough). Its natural habitat is in the human respiratory mucosa. Whooping Cough, or pertussis, is a respiratory infection in which a “whooping” sound is produced when the sufferer breathes. Pertussis kills an estimated 300,000 children annually, most of which occur in developing countries. [6]
Genome structure
Bordetella pertussis strain Tohama I has its complete genome sequenced. The genome consists of 1 circular chromosome with 4,086,189 nucleotides (3867 genes). Approximately 67% of the genome is GC rich and its coding density is 82% (1056 bp/gene). [10]
The IncP-1 beta plasmid pBP136 from Bordetella pertussis is also sequenced. It contains 41,268 bp nucleotides and carries 46 ORFs. Two of the ORFs have similar genes with unknown function to a plant pathogen called “Xylella fastidiosa”. pBP136 plasmid do not contain any accessory genes that code for antibiotics, mercury resistance, or xenobiotic degradation. Its role in the bacteria is unclear and is still under investigation. [9]
Cell structure and metabolism
Ecology
Pathology
Application to Biotechnology
Current Research
References
Edited by Linda Wang a student of Rachel Larsen and Kit Pogliano
