Leishmania donovani: Difference between revisions
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Revision as of 13:08, 8 December 2021
Introduction
Leishmania donovani is a parasite that infects mainly the human phagocyte system. The infection is transmitted to humans through sandflies, and is responsible for multiple forms of leishmaniasis or kala-azar in extreme cases. Its life cycle contains both a flagellated promastigote stage where it lives in the digestive system of sandflies, and an unflagellated amastigote stage that exists within the human host. The promastigote stage is injected into the bloodstream by a sandfly, and must be phagocytosed by a macrophage to begin the process of infection and cannot directly penetrate the cell. Once inside a cell, promastigotes transform into their amastigote stage and begin to multiply and eventually lyse the cell. When a new sandfly takes a blood meal from the host, it takes up amastigotes from the bloodstream, which transform into promastigotes in the sandfly's digestive tract to restart the process.
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Section 1 Methods of Infection
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Section 2 Microbiome
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References
- ↑ Division of Parasitic Diseases and Malaria. "Leishmaniasis" 2017. Center for Disease Control
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
- ↑ Parmar, Naveen, Pragya Chandrakar, and Susanta Kar. "Leishmania Donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides Plus IFN-Gamma)/M(IL-10) Polarization." The Journal of Immunology (1950) 204, no. 10 (2020): 2762-2778.
Edited by Iris Pardue, student of Joan Slonczewski for BIOL 116 Information in Living Systems, 2021, Kenyon College.