Probiotic Lactobacillus and Promotion of Tumor Growth: Difference between revisions

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<br>Logan Gusmano</br>
<br>Logan Gusmano</br>
==Introduction==
==Introduction==
Lactobacillus, a Gram-Positive, non spore forming firmicute, rod-shaped Bacilli bacterium inhabits the digestive tract of mammalian organism as a significant probiotic required for the digestion and breakdown of lactose in stable gut microbiome. Lactobacillus is classified into 3 distinct groups based on metabolic pathways, Obligately Facultatively homofermentative, and Obligately heterofermentative, each are significantly different in the products produced by the metabolic pathways of each species. Lactobacillus is a lactic acid bacteria (LAB) capable of proliferating in environments of low pH, tolerating the pH level in mammalians gut microbiome, and break down lactose present in the environment, promoting a health gut microbiome. However, in novel research, it has been discovered that lactobacillus has detrimental effects lessening the efficiency of anticancer medications.
Lactobacillus is a Gram-Positive, non-spore forming firmicute, rod-shaped Bacilli bacteria that inhabits the gastrointestinal tract of mammalian organisms gut microbiota. Lactobacillus, also known as Acidophilus, is a common probiotic required for the digestion and breakdown of lactose in a stable gut microbiome.  
 
Lactobacillus is classified into 2 distinct groups based on metabolic pathways, Obligately Facultatively homofermentative, and Obligately heterofermentative, each are significantly different in the products produced by the metabolic pathways of each species. Obligately Facultatively homofermentative lactobacilli refers to a group of microbes that ferment a majority of hexoses into the metabolite lactic acid. Heterofermentative Lactobacilli on the other hand ferment glucose producing not only lactic acid, but also ethanol and carbon dioxide.
 
Classified as a lactic acid bacterium (LAB, Leuconostocaceae), Lactobacilli are capable of proliferating in environments of low pH, tolerating the pH level in the mammalian gut microbiome, and breaking down lactose into the metabolite lactic acid. Although lactobacillus is considered to be a common microbe consumed by mammals through fermented products, in novel research, it has been discovered that lactobacillus could promote detrimental effects to the host's immune defenses targeting tumor proliferation. As stated by a published research paper from Vrije Universiteit Brussel, one of the byproducts of lactobacillus metabolism, lactic acid, has the biological capability of weakening the antitumor defenses of mammals.
 


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Revision as of 20:00, 8 March 2022

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Logan Gusmano

Introduction

Lactobacillus is a Gram-Positive, non-spore forming firmicute, rod-shaped Bacilli bacteria that inhabits the gastrointestinal tract of mammalian organisms gut microbiota. Lactobacillus, also known as Acidophilus, is a common probiotic required for the digestion and breakdown of lactose in a stable gut microbiome.

Lactobacillus is classified into 2 distinct groups based on metabolic pathways, Obligately Facultatively homofermentative, and Obligately heterofermentative, each are significantly different in the products produced by the metabolic pathways of each species. Obligately Facultatively homofermentative lactobacilli refers to a group of microbes that ferment a majority of hexoses into the metabolite lactic acid. Heterofermentative Lactobacilli on the other hand ferment glucose producing not only lactic acid, but also ethanol and carbon dioxide.

Classified as a lactic acid bacterium (LAB, Leuconostocaceae), Lactobacilli are capable of proliferating in environments of low pH, tolerating the pH level in the mammalian gut microbiome, and breaking down lactose into the metabolite lactic acid. Although lactobacillus is considered to be a common microbe consumed by mammals through fermented products, in novel research, it has been discovered that lactobacillus could promote detrimental effects to the host's immune defenses targeting tumor proliferation. As stated by a published research paper from Vrije Universiteit Brussel, one of the byproducts of lactobacillus metabolism, lactic acid, has the biological capability of weakening the antitumor defenses of mammals.




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Classification and Biological Structure

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Metabolism and interaction with the Environment

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Interaction with Pharmaceutics and Chemotherapies

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Metabolism and Byproducts

Conclusion

References

  1. ↑ 1.0 1.1 Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
  2. ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2022, Kenyon College

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