The Gut Microbiome and Parkinson's Disease: Difference between revisions
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Studying the relationship between Parkinson's Disease and gut microbiota can be difficult because the gut microbiome is easily influenced by medications and diet. Therefore, studies that attempt to control for these factors are particularly valuable for elucidating the connection between Parkinson's and the gut. One study attempted to do so by recruiting newly diagnosed and unmedicated Parkinson's disease patients in addition to medicated patients with long-term disease progression. Controls were established using patient family members and patients visiting the diagnosing hospital for unrelated reasons. Using antibiotics or having other gut-related diseases constituted grounds for expulsion from the study. | Studying the relationship between Parkinson's Disease and gut microbiota can be difficult because the gut microbiome is easily influenced by medications and diet. Therefore, studies that attempt to control for these factors are particularly valuable for elucidating the connection between Parkinson's and the gut. One study attempted to do so by recruiting newly diagnosed and unmedicated Parkinson's disease patients in addition to medicated patients with long-term disease progression. Controls were established using patient family members and patients visiting the diagnosing hospital for unrelated reasons. Using antibiotics or having other gut-related diseases constituted grounds for expulsion from the study <ref name=Barichella>Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., Pinelli, G., De Bellis, G., Zecca, L., Cereda, E., Consolandi, C. and Pezzoli, G. (2019). "Unraveling Gut Microbiota in Parkinson's Disease and Atypical Parkinsonism. <i>Movement Disorders</i>, vol. 34, 396-405. https://doi.org/10.1002/mds.27581</ref> | ||
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Fecal samples were collected from all patients and used to extract bacterial DNA. The 16S rRNA gene was amplified and sequenced using Illumina sequencing. The results were taxonomically arranged as measures of bacterial diversity and relative abundance of bacterial genera. | Fecal samples were collected from all patients and used to extract bacterial DNA. The 16S rRNA gene was amplified and sequenced using Illumina sequencing. The results were taxonomically arranged as measures of bacterial diversity and relative abundance of bacterial genera. | ||
Revision as of 23:29, 28 March 2022
Section
By Rebecca Hölzel
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Section 2
Include some current research, with at least one figure showing data.
Abnormal Gut Microbiome
The conditions that contribute to the development of Parkinson's Disease are likely very complex. A growing body of research has indicated, however, that the gut microbiome may play a key role in disease development and progression. Parkinson's Disease is commonly associate with abnormal gut microbiomes, including increased and decreased counts of bacteria normally found in healthy individuals [3].
Studying the relationship between Parkinson's Disease and gut microbiota can be difficult because the gut microbiome is easily influenced by medications and diet. Therefore, studies that attempt to control for these factors are particularly valuable for elucidating the connection between Parkinson's and the gut. One study attempted to do so by recruiting newly diagnosed and unmedicated Parkinson's disease patients in addition to medicated patients with long-term disease progression. Controls were established using patient family members and patients visiting the diagnosing hospital for unrelated reasons. Using antibiotics or having other gut-related diseases constituted grounds for expulsion from the study [4]
Fecal samples were collected from all patients and used to extract bacterial DNA. The 16S rRNA gene was amplified and sequenced using Illumina sequencing. The results were taxonomically arranged as measures of bacterial diversity and relative abundance of bacterial genera.
Section 3
Include some current research, with at least one figure showing data.
Section 4
Conclusion
References
- ↑ Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
- ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.
- ↑ Sampson, Timothy. (2020). "The Impact of Indigenous Microbes on Parkinson's Disease." Neurobiology of Disease, vol. 135. https://doi.org/10.1016/j.nbd.2019.03.014
- ↑ Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., Pinelli, G., De Bellis, G., Zecca, L., Cereda, E., Consolandi, C. and Pezzoli, G. (2019). "Unraveling Gut Microbiota in Parkinson's Disease and Atypical Parkinsonism. Movement Disorders, vol. 34, 396-405. https://doi.org/10.1002/mds.27581
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2022, Kenyon College
