The Gut Microbiome and Parkinson's Disease: Difference between revisions

From MicrobeWiki, the student-edited microbiology resource
Line 1: Line 1:
<!-- Do not edit this line-->{{Curated}}
<!-- Do not edit this line-->{{Curated}}
==Section==
[[Image:PHIL_22882_lores.jpg|thumb|300px|right|This illustration depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. The photo credit for this image belongs to Alissa Eckert, who is a medical illustrator at the [http://www.cdc.gov/ CDC].]]
<br>By Rebecca Hölzel<br>
<br>At right is a sample image insertion.  It works for any image uploaded anywhere to MicrobeWiki.<br><br>The insertion code consists of:
<br><b>Double brackets:</b> [[
<br><b>Filename:</b> PHIL_1181_lores.jpg
<br><b>Thumbnail status:</b> |thumb|
<br><b>Pixel size:</b> |300px|
<br><b>Placement on page:</b> |right|
<br><b>Legend/credit:</b> Electron micrograph of the Ebola Zaire virus. This was the first photo ever taken of the virus, on 10/13/1976. By Dr. F.A. Murphy, now at U.C. Davis, then at the [http://www.cdc.gov/ CDC]. Every image requires a link to the source. Go to upload file.
<br><b>Closed double brackets:</b> ]]
<br><br>Other examples:
<br><b>Bold</b>
<br><i>Italic</i>
<br><b>Subscript:</b> H<sub>2</sub>O
<br><b>Superscript:</b> Fe<sup>3+</sup>
<br>
<br>
Sample citations: <ref name=aa>[http://www.plosbiology.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pbio.1000005&representation=PDF Hodgkin, J. and Partridge, F.A. "<i>Caenorhabditis elegans</i> meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.]</ref>
<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847443/ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.]</ref>
<br><br>A citation code consists of a hyperlinked reference within "ref" begin and end codes.
<br>To repeat the citation for other statements, the reference needs to have a names: "<ref name=aa>"
<br> The repeated citation works like this, with a forward slash.<ref name=aa/>
==Abnormal Gut Microbiome==
==Abnormal Gut Microbiome==
The conditions that contribute to the development of Parkinson's Disease are likely very complex. A growing body of research has indicated, however, that the gut microbiome may play a key role in disease development and progression. Parkinson's Disease is commonly associate with abnormal gut microbiomes, including increased and decreased counts of bacteria normally found in healthy individuals <ref name=Sampson>Sampson, Timothy. (2020). "The Impact of Indigenous Microbes on Parkinson's Disease." <i>Neurobiology of Disease</i>, vol. 135. https://doi.org/10.1016/j.nbd.2019.03.014</ref>.
The conditions that contribute to the development of Parkinson's Disease are likely very complex. A growing body of research has indicated, however, that the gut microbiome may play a key role in disease development and progression. Parkinson's Disease is commonly associate with abnormal gut microbiomes, including increased and decreased counts of bacteria normally found in healthy individuals <ref name=Sampson>Sampson, Timothy. (2020). "The Impact of Indigenous Microbes on Parkinson's Disease." <i>Neurobiology of Disease</i>, vol. 135. https://doi.org/10.1016/j.nbd.2019.03.014</ref>.

Revision as of 23:31, 28 March 2022

This is a curated page. Report corrections to Microbewiki.

Abnormal Gut Microbiome

The conditions that contribute to the development of Parkinson's Disease are likely very complex. A growing body of research has indicated, however, that the gut microbiome may play a key role in disease development and progression. Parkinson's Disease is commonly associate with abnormal gut microbiomes, including increased and decreased counts of bacteria normally found in healthy individuals [1].

Studying the relationship between Parkinson's Disease and gut microbiota can be difficult because the gut microbiome is easily influenced by medications and diet. Therefore, studies that attempt to control for these factors are particularly valuable for elucidating the connection between Parkinson's and the gut. One study attempted to do so by recruiting newly diagnosed and unmedicated Parkinson's disease patients in addition to medicated patients with long-term disease progression. Controls were established using patient family members and patients visiting the diagnosing hospital for unrelated reasons. Using antibiotics or having other gut-related diseases constituted grounds for expulsion from the study [2]
Fecal samples were collected from all patients and used to extract bacterial DNA. The 16S rRNA gene was amplified and sequenced using Illumina sequencing. The results were taxonomically arranged as measures of bacterial diversity and relative abundance of bacterial genera.

Section 3

Include some current research, with at least one figure showing data.

Section 4

Conclusion

References

  1. Sampson, Timothy. (2020). "The Impact of Indigenous Microbes on Parkinson's Disease." Neurobiology of Disease, vol. 135. https://doi.org/10.1016/j.nbd.2019.03.014
  2. Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., Pinelli, G., De Bellis, G., Zecca, L., Cereda, E., Consolandi, C. and Pezzoli, G. (2019). "Unraveling Gut Microbiota in Parkinson's Disease and Atypical Parkinsonism. Movement Disorders, vol. 34, 396-405. https://doi.org/10.1002/mds.27581



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2022, Kenyon College