Fannyhessea vaginae

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Classification

Bacteria; Actinimycetota; Actinomycetes ; Actinomycetales; Actinomycetaceae; Fannyhessea

Species

NCBI: [1]

Fannyhessea vaginae

Description and Significance

Fannyhessea Vaginae (formerly atopobium vaginae) is a gram positive cocci shaped bacterium highly specific to Bacterial Vaginosis (BV) (Lu ́cia G. V. Sousa et al, 2021).

As an anaerobe (low to no oxygen) F. Vaginae creates polymicrobial biofilms that layer the vaginal epithelial cells providing the anaerobic conditions for optimal growth (Lu ́cia G. V. Sousa et al, 2021). The Biofilms produced by this microbe serves as a diagnostic marker for BV which is vital as most detection methods for BV fail.

Genome Structure

The F. Vaginae genome is a linear chromosome. The primary genome DSM 15829 is sequenced at 1.5 mbp, with one of the total 19 different strains only 461 bp. Most of the genes are protein coding, with 1200 genes coding over 18,000 proteins.

DSM 15829 contain a 5s, 16s, 23s rRNA; and a 30s protein s6. Encoded in this genome are sucrose metabolic pathways, glycan biosynthesis, and termination factor rho. In addition the NusB protein involved in RNA biosynthesis within eubacteria is regulated by modulating transcription and antitermination efficiency.

Cell Structure, Metabolism and Life Cycle

This organism uses utilizes carbohydrates through a glycolysis and pentose phosphorous pathway. Anaerobic glycolytic pathway breaks down glycerin-p down to pyruvate to be used in the production of energy. Pentose Phosphorous pathway breaks down fructose-6p that can end up In the input of the glycolytic pathway. In a further complex fashion during the break down via the glycerin-p, at the pyruvate stage this organism can switch its metabolism into a anabolic pathway to build the amino acid methionine from the serine intermediate.

Ecology and Pathogenesis

Habitat; symbiosis; biogeochemical significance; contributions to environment.

If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.

References

[Sample reference] Takai, K., Sugai, A., Itoh, T., and Horikoshi, K. "Palaeococcus ferrophilus gen. nov., sp. nov., a barophilic, hyperthermophilic archaeon from a deep-sea hydrothermal vent chimney". International Journal of Systematic and Evolutionary Microbiology. 2000. Volume 50. p. 489-500.

Author

Page authored by John T., student of Prof. Bradley Tolar at UNC Wilmington.