Nocardioides carbamazepini

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"Nocardioides Carbamazepini" ScieneDirect.com

Classification

Bacteria, Actinomycetota, Actinomycetes, Propionibacteriales, Nocardiodaceae, Nocardioides.

Species

NCBI: [1]

"Nocardioides Carbamazepini"

Description and Significance

The significance of this microorganism is due to its relation to medicine and how it can limit the symptoms of epilepsy, bipolar disorder, and nerve damage, as well as degrade ibuprofen in the environment. It is a multifunctional organism that, if researched fully, could create a solution for both the environmental effect of pharmaceuticals along with providing an alternative medication to those suffering from the symptoms previously stated.

Genome Structure

Nocardioides carbamazepini’s genome structure is scaffolded and roughly 6.3 Mb in size. The content of this microorganism is not listed, but the strain of it is CBZ_1. It is assumed to be linear and there are no assembled chromosomes.

Cell Structure, Metabolism and Life Cycle

Nocardioides carbamazepine is a Gram-postive, aerobic, mesophole that is able to metabolize both catabolic and anabolic. There are six electron reductions that occur to metabolize alongside the enzymes. The cell structure for this organism is not highly researched, yet only the cell wall composition is known (LL-diaminopimelic acid, alanine, glutamic acid, glycine).

Ecology and Pathogenesis

The habitat for the Nocardioides carbamazepini microorganism is varied, as it and it’s related species have been shown to inhabit both natural and unnatural environments - there is research that has depicted both the Nocardioidaceae family (Nocardioides) and the variation of carbamazepini (noted as carbamazepine in some text) in agricultural regions and groundwater. There is minimal information regarding its environmental effects, however, there is running research regarding the degradation of this organism in groundwater due to the overuse of its pharmaceutical counterpart. The most common place that this microorganism can be found in is medical facilities and research, in which it is used to both alter and create the structure of medication. Nocardiodes carbamazepini is not capable of causing disease but has been shown to have a beneficial factor in a variety of medications, as stated above. Carbamazepine is the variation that is used to treat neurological issues such as epilepsy, nerve damage, and bipolar disorder, whereas Nocardiodes carbamazepini itself is used to biodegrade ibuprofen.

References

Benedek, T., Papai, M., Gharieb, K., Bedics, A., Tancsics, A., Daood, H., … Boka, K. (2022). Nocardioides carbamazepini sp. nov., an ibuprofen degrader isolated from a biofilm bacterial community enriched on carbamazepine. https://www.sciencedirect.com/science/article/pii/S0723202022000467?via%3Dihub

U.S. National Library of Medicine. (n.d.). Nocardioides carbamazepini - NCBI - NLM. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/datasets/taxonomy/2854259/

Pápai, M., Benedek, T., Táncsics, A., Bornemann, T. L., Plewka, J., Probst, A. J., Hussein, D., Maróti, G., Menashe, O., & Kriszt, B. (2023). Selective enrichment, identification, and isolation of diclofenac, ibuprofen, and carbamazepine degrading bacteria from a groundwater biofilm. Environmental Science and Pollution Research, 30(15), 44518–44535. https://doi.org/10.1007/s11356-022-24975-6

Prauser, H. (1976). Nocardioides, a new genus of the order Actinomycetales. microbiologyresearch.org. https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/00207713-26-1-58?crawler=true#:~:text=The%20organism%20is%20a%20gram,of%20a%20taxon%2Dspecific%20set.

Author

Page was authored by Karley Madden, a student of Prof. Bradley Tolar at UNC Wilmington. [[Category:Pages edited by students of Bradley Tolar at UNC Wilmington]]