User:JohnsonAE: Difference between revisions
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Describe the appearance, habitat, etc. of the organism, and why you think it is important. | Describe the appearance, habitat, etc. of the organism, and why you think it is important. | ||
Clostridium sordelli is an anaerobic, gram positive and spore forming bacterium. It has peritrichous flagella and its most common habitat is the soil but it is also found in intestines of animals and humans (1). Clostridium sordelli has both non-pathogenic strains and pathogenic strains. Its pathogenic strains are known to cause toxic shock syndrome in humans and enteritis in sheep and cattle (1 &). | Clostridium sordelli is an anaerobic, gram positive and spore forming bacterium. It has peritrichous flagella and its most common habitat is the soil but it is also found in intestines of animals and humans (1). Clostridium sordelli has both non-pathogenic strains and pathogenic strains. Its pathogenic strains are known to cause toxic shock syndrome in humans and enteritis in sheep and cattle (1 &). This bacterium is important because its pathogenic strain causes a lot of damages and sometimes death to the organism infected. I want to investigate what has been done to control its virulence and resistant strains. In addition, research on its non-pathogenic strain and its usefulness will be done. | ||
==Genome structure== | ==Genome structure== | ||
Revision as of 11:22, 10 May 2012
A Microbial Biorealm page on the genus JohnsonAE
Classification
Higher order taxa
Domain: Bacteria Phylum: Firmicutes Class: Clostridia Order: Clostridiales Family: Clostridiaceae
Species
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NCBI: Taxonomy |
Genus species
Sordelli
Description and significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
Clostridium sordelli is an anaerobic, gram positive and spore forming bacterium. It has peritrichous flagella and its most common habitat is the soil but it is also found in intestines of animals and humans (1). Clostridium sordelli has both non-pathogenic strains and pathogenic strains. Its pathogenic strains are known to cause toxic shock syndrome in humans and enteritis in sheep and cattle (1 &). This bacterium is important because its pathogenic strain causes a lot of damages and sometimes death to the organism infected. I want to investigate what has been done to control its virulence and resistant strains. In addition, research on its non-pathogenic strain and its usefulness will be done.
Genome structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
Cell structure and metabolism
Interesting features of cell structure; how it gains energy; what important molecules it produces.
An important molecule that Clostridium sordelli produces that aids it pathogenic strain in surviving is its toxins. Clostridium sordelli produces a variety of different toxins such as exotoxin, endotoxin and hemorrhagic toxin. Its endotoxin is released when its cell wall disintegrates (4).
Ecology
Habitat; symbiosis; contributions to the environment.
2) its present in viaginal microbiata and in gastrointestinal tracts of adult humans.
4) C. sordellii is part of the normal vaginal flora in about 10% of women. The clinical
aspects of C. sordellii bacteremia have been reviewed.15 Clinical infections of the vagina and/or uterus are usually prevented by the host’s innate immune system. 1
Pathology
How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
2) its a human pathologist
produce toxins in its veg state
c- sordelli infects post -pregancy suggests sex hormones might regulate its capacity to germinate and produce toxins. steroid hormones increase its germination rate
also causes diesease in animals
all copy paste (PRAPHARASE)
enteritis occurs in sheep, cattle, and foals after ingestion of C. sordellii spores
Penetrating trauma, injection of black tar heroin, and gynecological procedures are potential risk factors for infection in humans
Septic shock due to C. sordellii bacteremia results in 70% to 100% mortality rates (1, 4). C. sordellii infections of the female genital tract develop primarily after childbirth and less commonly following spontaneous or medical abortion (1, 11, 19, 50). This suggests that female steroidal sex hormones might play a role in the pathogenesis of infection.
We have recently speculated that the presence of increased amino acid levels during pregnancy together with high vaginal pH may provide the signaling for C. sordellii spore germination and infection establishment
Current Research and or Application to Biotechnology
Enter summaries of the most recent research and/or application to biotechnology here--at least three required Paper 2 can go here too
References
Edited by student of Dr. Lynn M Bedard, DePauw University http://www.depauw.edu
