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(Figure was adapted from Filomatori et al. (2006).)
 
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Figure was adapted from Filomatori et al. (2006).
In a study done by Helene Malet, et.al, the binding of the NS5 RNA-dependent RNA polymerase (RdRp) was tested for possible antiviral drugs.  The 5’ and 3’ terminal regions of the Flavivirus RNA genome form complementary cyclization sequences.  This structure is important for RNA replication.  The RdRp domain binds to the promoter stem loop A at the 5’ end (SLA) of the genome and initiates RNA synthesis using the 3’ end as a template.  Figure was adapted from Filomatori et al. (2006).

Latest revision as of 22:03, 15 April 2009

In a study done by Helene Malet, et.al, the binding of the NS5 RNA-dependent RNA polymerase (RdRp) was tested for possible antiviral drugs. The 5’ and 3’ terminal regions of the Flavivirus RNA genome form complementary cyclization sequences. This structure is important for RNA replication. The RdRp domain binds to the promoter stem loop A at the 5’ end (SLA) of the genome and initiates RNA synthesis using the 3’ end as a template. Figure was adapted from Filomatori et al. (2006).

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current18:51, 15 April 2009Thumbnail for version as of 18:51, 15 April 2009564 × 359 (46 KB)Knightj (talk | contribs)Figure was adapted from Filomatori et al. (2006).

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