Yellow fever virus: Difference between revisions
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===Description=== | ===Description=== | ||
Yellow Fever virus (YFV) was the first proven human-pathogenic virus in 1927(jvi); it is a Group IV positive-sense single stranded RNA virus due to its direct mRNA-like functions in a host cell (cdc). It belongs to the family ''Flaviviridae'' and genus Flavivirus. Yellow fever virus was the first classified in both of these taxonomies, hence the “flavi” Latin root for “yellow”. Arthropod vectors are the main source for the spread of Yellow fever virus (e.g. mosquitos) like many other viruses in the Flaviviridae family (e.g. Hepatitis). There is a great deal of symmetry involved in the near spherical structure of YFV, similar to the other Flavivirus (e.g. Dengue, West Nile). YFV was named for the disease it causes in humans, Yellow fever. Humans are a dead-end host, terminating the virus’s life cycle and consequently suffering from much harsh symptoms than its native host. Yellow Fever, as a disease, took notable attention beginning in Philadelphia in 1793, killing 9 percent of the population, again in 1878 along the Mississippi with a death toll of 20,000, and the last major outbreak in the United States occurred in New Orleans in 1905 with 452 deceased (pbs). The rapid decrease in outbreaks is attributed to the work of the US Army Medical Corps Yellow Fever Commission led by the Virginian physician Walter Reed during the Spanish-Cuban-American War. Reed used the work of Cuban scientist Carlos Finlay to prove the role of mosquitos, particularly Aedes aegypti, in transmitting the disease (what he believed at the time to be bacterial) and thus was able to develop sanitation techniques in reducing the mosquito population (yellow fever). Infected individuals are characterized by general flu-like symptoms that in 15% of cases develop into the more toxic phase; the disease accounts for 200,000 incidents with 30,000 deaths a year (who). | Yellow Fever virus (YFV) was the first proven human-pathogenic virus in 1927(jvi); it is a Group IV positive-sense single stranded RNA virus due to its direct mRNA-like functions in a host cell (cdc). It belongs to the family ''Flaviviridae'' and genus ''Flavivirus''. Yellow fever virus was the first classified in both of these taxonomies, hence the “flavi” Latin root for “yellow”. Arthropod vectors are the main source for the spread of Yellow fever virus (e.g. mosquitos) like many other viruses in the ''Flaviviridae'' family (e.g. Hepatitis). There is a great deal of symmetry involved in the near spherical structure of YFV, similar to the other ''Flavivirus'' (e.g. Dengue, West Nile). YFV was named for the disease it causes in humans, Yellow fever. Humans are a dead-end host, terminating the virus’s life cycle and consequently suffering from much harsh symptoms than its native host. Yellow Fever, as a disease, took notable attention beginning in Philadelphia in 1793, killing 9 percent of the population, again in 1878 along the Mississippi with a death toll of 20,000, and the last major outbreak in the United States occurred in New Orleans in 1905 with 452 deceased (pbs). The rapid decrease in outbreaks is attributed to the work of the US Army Medical Corps Yellow Fever Commission led by the Virginian physician Walter Reed during the Spanish-Cuban-American War. Reed used the work of Cuban scientist Carlos Finlay to prove the role of mosquitos, particularly ''Aedes aegypti'', in transmitting the disease (what he believed at the time to be bacterial) and thus was able to develop sanitation techniques in reducing the mosquito population (yellow fever). Infected individuals are characterized by general flu-like symptoms that in 15% of cases develop into the more toxic phase; the disease accounts for 200,000 incidents with 30,000 deaths a year (who). | ||
==Pathogenesis== | ==Pathogenesis== | ||
Revision as of 16:18, 22 July 2014
Etiology/Bacteriology
Taxonomy
ICTV Virus Classification
| Order = Unassigned | Family = Flaviviridae | Subfamily Unassigned | Genus = Flavivirus | Species = Yellow fever virus
Baltimore Classification
| Group= IV | Family = Flaviviridae | Subfamily Unassigned | Genus = Flavivirus | Species = Yellow fever virus
Description
Yellow Fever virus (YFV) was the first proven human-pathogenic virus in 1927(jvi); it is a Group IV positive-sense single stranded RNA virus due to its direct mRNA-like functions in a host cell (cdc). It belongs to the family Flaviviridae and genus Flavivirus. Yellow fever virus was the first classified in both of these taxonomies, hence the “flavi” Latin root for “yellow”. Arthropod vectors are the main source for the spread of Yellow fever virus (e.g. mosquitos) like many other viruses in the Flaviviridae family (e.g. Hepatitis). There is a great deal of symmetry involved in the near spherical structure of YFV, similar to the other Flavivirus (e.g. Dengue, West Nile). YFV was named for the disease it causes in humans, Yellow fever. Humans are a dead-end host, terminating the virus’s life cycle and consequently suffering from much harsh symptoms than its native host. Yellow Fever, as a disease, took notable attention beginning in Philadelphia in 1793, killing 9 percent of the population, again in 1878 along the Mississippi with a death toll of 20,000, and the last major outbreak in the United States occurred in New Orleans in 1905 with 452 deceased (pbs). The rapid decrease in outbreaks is attributed to the work of the US Army Medical Corps Yellow Fever Commission led by the Virginian physician Walter Reed during the Spanish-Cuban-American War. Reed used the work of Cuban scientist Carlos Finlay to prove the role of mosquitos, particularly Aedes aegypti, in transmitting the disease (what he believed at the time to be bacterial) and thus was able to develop sanitation techniques in reducing the mosquito population (yellow fever). Infected individuals are characterized by general flu-like symptoms that in 15% of cases develop into the more toxic phase; the disease accounts for 200,000 incidents with 30,000 deaths a year (who).
