From MicrobeWiki, the student-edited microbiology resource
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| Y. enterocolitica strain 8081 has a circular DNA chromosome of size 4,615,899bp. The number of coding sequences (CDSs) is 4037 with 7 rRNA operons and 81 tRNA. The GC content of the chromosome is 47.27%. Average gene size is 968 bp. The chromosome also contains 60 IS elements and 4 Prophage regions. In addition to the chromosome, Y. enterocolitica also has four other plasmids. pYVe8081 is 67,721nt in length(22), p29807 is 2682 nt (23), pYVa127/90 is 66591nt long and pYVe227 is 69673 nt (24). In terms of pathogenicity, Y. enterocolitica needs both chromosome and plasmid to work as a pathogen, because both the chormosome and the pYV pathogenic plasmid contains gene necessary for virulence(11-1,2). Also, the virulent strains contain plasmid that encodes genes for “low-Ca21 response”, which give rise to pathogenic properties (24).
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| The unique features that distinguish Y. enterocolitica genome from all other Yersinia species are the coenzyme B12 biosynthetic (cbi) and 1,2-propanediol-degradation (pdu). These genes clusters are located on a genomic island that is about 40kb in size. Coenzyme B12 is needed to breakdown 1,2-propanediol for carbon and energy utilization, and it is produced only when no Oxygen is present in the environment. It has been suggested that the pdu operon is the loci for lateral gene transfer in both Salmonella and E. Coli divergence.(22) This is interesting because Salmonella also has cib and pdu genes that are very similar to those in. [22-30,31]
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Revision as of 01:44, 4 June 2007
