Streptobacillus Moniliformis: Difference between revisions
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RBF is not well known in the United States, so data on this disease is limited (4). With increased crowding in cities where wild rodents tend to thrive, coupled with the increase in children owning rodents, people may be more susceptible to S. moniliformis than they were in the past (5). Current research focuses on advancements in detection and identification methods (2). | RBF is not well known in the United States, so data on this disease is limited (4). With increased crowding in cities where wild rodents tend to thrive, coupled with the increase in children owning rodents, people may be more susceptible to S. moniliformis than they were in the past (5). Current research focuses on advancements in detection and identification methods (2). | ||
= | =3. History= | ||
S. moniliformis was first isolated from the blood of a patient who had previously been bitten by a rat in 1914. It was then given one of its first names, Streptothrix muris ratti (6). In 1925, the bacterium attained its current name, Streptobacillus moniliformis (7). S. moniliformis has also been known as “Haverhillia multiformis”, which was named after a 1926 outbreak in Haverhill, MA that caused Haverhill fever, which is a form of RBF (8). | |||
=3. Genome structure= | =3. Genome structure= | ||
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? | Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence? | ||
Revision as of 14:45, 6 December 2021
1. Classification
a. Higher order taxa
The scientific classification for S. moniliformis is as followed, according to NCBI (1): Domain - Bacteria Phylum - Fusobacteria Class - Fusobacteriaceae Order - Leptotrichiaceae Genus - Streptobacillus Species - Moniliformis
2. Introduction
The bacterium Streptobacillus moniliformis is a Gram-negative bacterium known for causing RBF (Rat Bite Fever) in humans. RBF is a zoonotic disease typically caused by direct contact with an infected rodent, such as via a rat bite (2), but it can also be contracted by indirect contact with an infected rodent through consumption of contaminants (Haverhill fever) (3). When humans are infected with S. moniliformis, the distinguishable symptoms consist of high fevers, rashes, joint and muscle pain, nausea, vomiting, and headaches (2). Children are the main population that is affected by this disease, due to the increase in children owning pets such as mice, rats, guinea pigs, hamsters, etc. (4). RBF is not well known in the United States, so data on this disease is limited (4). With increased crowding in cities where wild rodents tend to thrive, coupled with the increase in children owning rodents, people may be more susceptible to S. moniliformis than they were in the past (5). Current research focuses on advancements in detection and identification methods (2).
3. History
S. moniliformis was first isolated from the blood of a patient who had previously been bitten by a rat in 1914. It was then given one of its first names, Streptothrix muris ratti (6). In 1925, the bacterium attained its current name, Streptobacillus moniliformis (7). S. moniliformis has also been known as “Haverhillia multiformis”, which was named after a 1926 outbreak in Haverhill, MA that caused Haverhill fever, which is a form of RBF (8).
3. Genome structure
Describe the size and content of the genome. How many chromosomes? Circular or linear? Other interesting features? What is known about its sequence?
4. Cell structure
Interesting features of cell structure. Can be combined with “metabolic processes”
5. Metabolic processes
S. moniliformis is a chemoheterotroph, using carbohydrates as an energy source, and monosaccharides and starch as carbon sources (12). The bacterium does not produce catalase or oxidase enzymes, suggesting that the bacterium uses fermentation for metabolism. The bacterium produces acid from metabolism of glucose, fructose, maltose, and starch, but no gas (12). There is disagreement regarding the oxygen requirements of the bacterium: S. moniliformis has been classified as a facultative anaerobe (13) and a microaerophile (14), while S. moniliformis isolated from guinea pigs specifically has been shown to behave as an obligate anaerobe (15).
6. Ecology
Habitat; symbiosis; contributions to the environment.
7. Pathology
How does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
8. Current Research
Include information about how this microbe (or related microbes) are currently being studied and for what purpose
9. References
It is required that you add at least five primary research articles (in same format as the sample reference below) that corresponds to the info that you added to this page. [Sample reference] Faller, A., and Schleifer, K. "Modified Oxidase and Benzidine Tests for Separation of Staphylococci from Micrococci". Journal of Clinical Microbiology. 1981. Volume 13. p. 1031-1035.
