Tomasiella immunophila: Difference between revisions
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If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.<br><br> | If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.<br><br> | ||
T.imunnophila resides in the gut of mice hosts where it metabolizes Immunoglobulin A (IgA) for N-acetyluramic acid (MurNAc). <br> | |||
In metabolizing IgA antibodies, which protect the gut, it leaves the host's immune system compromised to opportunistic pathogens.<br> | |||
Further study of T.immunophila could show promising results aiding in treatments of similar illnesses. <br> | |||
==References== | ==References== | ||
Revision as of 22:57, 2 December 2024
Tomasiella immunophila
Legend. Image credit: Name or Publication.]]
Classification
Domain Bacteria;
Phylum Pseudomonadota;
Class Gammaproteobacteria;
Order Enterobacterales;
Family Enterobacteriaceae
Species
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NCBI: [1] |
There is no NCBI page currently listed for the species Tomasiella Immunophila
Description and Significance
Describe the appearance, habitat, etc. of the organism, and why you think it is important.
Tomasiella immunophila is a gram-negative, rod-shaped, auxotrophic bacterium. When the species is cultured on a plate its physical characteristics appear to be smooth, moist, and translucent. The species was recently isolated from the intestinal tract of laboratory mice being investigated for microbiome symbionts at the Cleveland Clinic. (Quiche Lu et al, 2024) The mammalian microbiome maintains an internal temperature of around 37°C (98.6°F). This would classify T. immunophila as a mesophilic microbe.
Genome Structure
Though it is not completely researched as to the structure of the genome or its size. Based on the family it resides in, the Muribaculaceae family, it can be assumed for now that it is mostly likely a single, circular chromosome. Something of significance to note is the bacteria's auxotrophy for N-acetylmuramic acid (MurNAc). This is vital for the production of peptidoglycan in the bacterial cell wall. This leads to a lack of key enzymes in the cell, GlmS, MurA, and MurB.
Cell Structure, Metabolism and Life Cycle
Interesting features of cell structure; how it gains energy; what important molecules it produces.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
T.imunnophila resides in the gut of mice hosts where it metabolizes Immunoglobulin A (IgA) for N-acetyluramic acid (MurNAc).
In metabolizing IgA antibodies, which protect the gut, it leaves the host's immune system compromised to opportunistic pathogens.
Further study of T.immunophila could show promising results aiding in treatments of similar illnesses.
References
Lu Q, Hitch TCA, Zhou JY, Dwidar M, Sangwan N, Lawrence D, Nolan LS, Espenschied ST, Newhall KP, Han Y, Karell PE, Salazar V, Baldridge MT, Clavel T, Stappenbeck TS. A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency. Science. 2024 Sep 27;385(6716):eadk2536. doi: 10.1126/science.adk2536. Epub 2024 Sep 27. PMID: 39325906.
Author
Page authored by Jackson Gainey, Olivia Farrar, John Folger, & Logan Tamadon, students of Prof. Bradley Tolar at UNC Wilmington.
