Bifidobacterium: Difference between revisions
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==Ecology== | ==Ecology== | ||
While'' Bifidobacterium infantis, B. brevi, ''and ''B. longum ''are the largest bacteria | While'' Bifidobacterium infantis, B. brevi, ''and ''B. longum ''are the largest group of bacteria in the intestine of infants, ''Bifidobacteria'' are said to be only the 3rd or 4th largest group in adults (and comprise only 3-6% of adult fecal flora). The number of ''Bifidobacteria'' actually decline in the human body with age. In infants who are breast-fed, ''Bifidobacteria'' constitute about 90% of their intestinal bacteria; however, this number is lower in bottle-fed infants. When breast-fed infants' diets are changed to cows milk and solid food, ''Bifidobacteria'' are joined by rising numbers of other bacteria found in the human body such as ''Bacteroides'' and ''Streptococci lactobacilli''. The lower number of ''Bifidobacteria ''in formula-fed babies might account for a higher risk of diarrhea and allergies that is usually associated with babies who aren't breast-fed; in addition, because ''Bifidobacteria'' produces lactic acid instead of gas (like ''E. coli)'', infants and people in general with more ''Bifidobacteria'' than other bacteria will have less gas and digestive problems. There is also a significant difference in the incidence of antibiotic-associated diarrhea in the children receiving probiotic-supplemented (inriched with ''Bifidobacterium'') formula (16%) than nonsupplemented formula (31%). | ||
''Bifidobacteria'' as well as other beneficial bacteria can be found in fermented dairy foods, especially yogurt. Eating substances rich with these probiotics is a sort of home remedy for diarrhea, vaginitis, and yeast infections because it promotes the growth of these as opposed to other bacteria. B. infantis has been proven to dramatically reduce irritable bowel sydrome (IBS) in patients and if given alone can almost normalize the patient. | ''Bifidobacteria'' as well as other beneficial bacteria can be found in fermented dairy foods, especially yogurt. Eating substances rich with these probiotics is a sort of home remedy for diarrhea, vaginitis, and yeast infections because it promotes the growth of these as opposed to other bacteria. B. infantis has been proven to dramatically reduce irritable bowel sydrome (IBS) in patients and if given alone can almost normalize the patient. | ||
Revision as of 20:44, 1 June 2006
Classification
Higher order taxa:
Bacteria; Actinobacteria; Actinobacteria (class); Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae
Species:
B. angulatum; B. animalis; B. asteroides; B. bifidum; B. boum; B. breve; B. catenulatum; B. choerinum; B. coryneforme; B. cuniculi; B. dentium; B. gallicum; B. gallinarum; B indicum; B. longum; B. magnum; B. merycicum; B. minimum; B. pseudocatenulatum; B. pseudolongum; B. psychraerophilum; B. pullorum; B. ruminantium; B. saeculare; B. scardovii; B. simiae; B. subtile; B. thermacidophilum; B. thermophilum; B. urinalis; B. sp.
Description and Significance
Bifidobacteria, called probiotics, are a natural part of the bacterial flora in the human body and have a symbiotic bacteria-host relationship with humans. B. longum promotes good digestion, boosts the immune system, and produces lactic and acetic acid that controls intestinal pH. These bacteria also inhibit the growth of Candida albicans, E. coli, and other bacteria that have more pathogenic qualities than Bifidobacteria.
Genome Structure
The circular chromosome of Bifidobacterium longum has a genome approximately 2,260,000 bp in length with a 60% G-C content. More research is being done on sequencing other species of Bifidobacterium, especially to understand its probiotic qualities.
Cell Structure and Metabolism
Bifidobacterium is a Gram-positive, anaerobic, branched rod-shaped bacterium. In the intestines, they ferment sugars to produce lactic acid. The B. longum genome codes for many proteins specialized for the catabolism of oligosaccharides. This bacterium also is able to use so-called "nondigestible" plant polymers or host-derived glycoproteins and glycoconjugates; it is thought that Bifidobacterium's ability to compete with other gastrointestinal bacteria and occupy a large percentage in the bacterial flora of the gastrointestinal region might be partly due to the large variety of molecules that it is able to use for energy (Schell et al. 2002). Bifidobacteria have a unique hexose metabolism that occurs through a phosphoketolase pathway. This pathway, called the bifid shunt, uses the key enzyme frutose-6-phosphate phosphoketolase (F6PPK) and is the generally used as a diagnostic test for this Bifidobacteria because it's not found in other gram-positive intestinal bacteria.
Ecology
While Bifidobacterium infantis, B. brevi, and B. longum are the largest group of bacteria in the intestine of infants, Bifidobacteria are said to be only the 3rd or 4th largest group in adults (and comprise only 3-6% of adult fecal flora). The number of Bifidobacteria actually decline in the human body with age. In infants who are breast-fed, Bifidobacteria constitute about 90% of their intestinal bacteria; however, this number is lower in bottle-fed infants. When breast-fed infants' diets are changed to cows milk and solid food, Bifidobacteria are joined by rising numbers of other bacteria found in the human body such as Bacteroides and Streptococci lactobacilli. The lower number of Bifidobacteria in formula-fed babies might account for a higher risk of diarrhea and allergies that is usually associated with babies who aren't breast-fed; in addition, because Bifidobacteria produces lactic acid instead of gas (like E. coli), infants and people in general with more Bifidobacteria than other bacteria will have less gas and digestive problems. There is also a significant difference in the incidence of antibiotic-associated diarrhea in the children receiving probiotic-supplemented (inriched with Bifidobacterium) formula (16%) than nonsupplemented formula (31%).
Bifidobacteria as well as other beneficial bacteria can be found in fermented dairy foods, especially yogurt. Eating substances rich with these probiotics is a sort of home remedy for diarrhea, vaginitis, and yeast infections because it promotes the growth of these as opposed to other bacteria. B. infantis has been proven to dramatically reduce irritable bowel sydrome (IBS) in patients and if given alone can almost normalize the patient.
References
Healthnotes: Probiotics. 2002.
Doe Joint Genome Institute: Bifidobacterium longum. 2004
Leahy, S, et al. "The genome sequence of Bifidobacterium breve." University College Cork, Ireland.
