User:U AOdewale: Difference between revisions
U AOdewale (talk | contribs) |
U AOdewale (talk | contribs) |
||
| Line 1: | Line 1: | ||
==Genome structure== | ==Genome structure== | ||
Revision as of 08:02, 17 December 2008
Genome structure
Genomically, astrovirus have positive-sense, single stranded, RNA genome which are about 6.8 to 7.9 kb in length. Their genomes have three open reading frames (ORFs) which are organized from 5’ to 3'. ORF1a encodes a serine protease, ORF1b encodes the RNA dependent polymerase and ORF 2 encodes the structural proteins. The space between the ORF1b (open reading frame) stop codon and the ORF2 is 18 nucleotides. There is also a translation machinery for ORF1b, although its sequence do not give a clear picture to the overall translation strategy. The frameshift structure allows for the translation of ORF1a and ORF1b to occur in order for polyprotein to cleave into functional subunits.
Virion Structure
Turkey Astrovirus are non-eneveloped, spherical, icosahedral capsid of 28 to 30nm. On the surface, they appear rough, spikes protruding from the 12 verticals.
Ecology
Habitat; symbiosis; contributions to the environment.
Pathology
After the turkey has been infected and then consumed by human, it typically cause watery diarrhea which lasts for about 2-4 days. It can also cause although less commonly, vomiting, headache, fever, abdominal pains, and anorexia in children under 2, elderly and immunocompromised people. Diarrhea is the third leading infectious cause of death worldwide.
Current Research
Enter summarries of the most rescent research here--at least three required
References
Edited by student of Emily Lilly at University of Massachusetts Dartmouth.
