Burkholderia pseudomallei

A Microbial Biorealm page on the genus Burkholderia pseudomallei

Classification

Higher order taxa

Bacteria; Proteobacteria; Beta Proteobacteria; Burkholderiales; Burkholderiaceae

Species

NCBI: Taxonomy

Burkholderia pseudomallei

Description and significance

Burkholderia pseudomallei is a gram negative bacterium with dimensions 2-5μm in length and .4-.8μm in diameter in the shape of a rod. This bacterium is aerobic and has flagellum that provides motility. It found in the soil and water and is endemic to Southeast Asia and Northern Australia. Its optimal growth occurs at the temperature of 40°C and a neutral or slightly acidic pH. Burkholderia pseudomallei is significant in its role of causing a disease known as melioidosis, which currently doesn’t have a vaccine.

Genome structure

The genome consists of two chromosomes and each has a different role. The lager chromosome made up of 4.07 megabase pairs contain genes that are essential for “housekeeping work” such as metabolism and cell growth. The other chromosome is made up of 3.17 megabase pairs and contains genes that are essential for adaptation and survival in different environments. Careful scrutiny of the two chromosomes indicate that they each gained genomic islands and possess double the amount of DNA normally present in other bacterium to better adapt to the environment in order to survive.

Cell structure and metabolism

Describe any interesting features and/or cell structures; how it gains energy; what important molecules it produces.

Ecology

Describe any interactions with other organisms (included eukaryotes), contributions to the environment, effect on environment, etc.

Pathology

Burkholderia pseudomallei is a human and animal pathogen and is the cause of melioidosis, which is a disease native to Southeast Asia and northern Australia. It releases exo and endo toxins but their role in instigating the symptoms of melioidosis is not yet fully understood. Nevertheless, infection is spread through ingestion or contact of bacteria onto open skin wounds or through the inhalation of the aerosolized Burkholderia pseudomallei. Melioidosis can be classified as acute or chronic depending on the incubation time before symptoms appear. Burkholderia pseudomallei mimics tuberculosis in its ability o lay dormant without showing any symptoms for years. Common symptoms include fever, formation of abscess on various parts of the body such as the brain, osteomyelitis, bacteremia and various diseases of the heart, lungs and kidney such as pneumonia. Burkholderia pseudomallei was thought to have biological warfare potential and it’s virulence is made evident by being listed as a “Category B agent” by the US centers for Disease Control.

Application to Biotechnology

Does this organism produce any useful compounds or enzymes? What are they and how are they used?

Current Research

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References

http://www.sanger.ac.uk/Info/Press/2004/040914.shtml http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15377794

http://en.wikipedia.org/wiki/Burkholderia_pseudomallei

http://en.wikipedia.org/wiki/Melioidosis

Edited by Jin-Mo O