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(|<br><b>Figure 3.</b> Activity Confirmation and Target Identification for N-(2-(4-methoxyphenoxy) ethyl)-3,5-dinitrobenzamide (DNB1) (A) Chemical structure of DNB1 (B) Results of intracellular assay f) |
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<br><b>Figure 3.</b> Activity Confirmation and Target Identification for N-(2-(4-methoxyphenoxy) ethyl)-3,5-dinitrobenzamide (DNB1) (A) Chemical structure of DNB1 (B) Results of intracellular assay from DNB1 of the benzamide scaffold (C) Inhibition of the in vitro growth fluorescence assays by DNB1 (D) Images of human macrophages infected with <i>M. tuberculosis</i> containing GFP after exposure to DNB1 and INH (5 µM) and DMSO for 7 days. NI: non infected (E) Dose-response curve for DNB1 on mouse macrophages infected with <i>M. tuberculosis</i> containing GFP and human macrophages after 5 days for 2 independent experiments (F) Gel showing the effect of DNB1 on the synthesis of decaprenyl-phospho-arabinose (DPA) by cell-free extracts of <i>Mycobacterium smegmatis</i> [http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000645 Christophe et al. [[#References|[2]]] | |||
Latest revision as of 23:20, 15 April 2015
Figure 3. Activity Confirmation and Target Identification for N-(2-(4-methoxyphenoxy) ethyl)-3,5-dinitrobenzamide (DNB1) (A) Chemical structure of DNB1 (B) Results of intracellular assay from DNB1 of the benzamide scaffold (C) Inhibition of the in vitro growth fluorescence assays by DNB1 (D) Images of human macrophages infected with M. tuberculosis containing GFP after exposure to DNB1 and INH (5 µM) and DMSO for 7 days. NI: non infected (E) Dose-response curve for DNB1 on mouse macrophages infected with M. tuberculosis containing GFP and human macrophages after 5 days for 2 independent experiments (F) Gel showing the effect of DNB1 on the synthesis of decaprenyl-phospho-arabinose (DPA) by cell-free extracts of Mycobacterium smegmatis Christophe et al. [2
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