Gas gangrene (Clostridial myonecrosis): Difference between revisions

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[[Image:kappatox1.jpeg|thumb|200px|right|Structure of alpha-toxin. Two separate domains are pictured with N- and C-domains and Zn2+ and possible Ca2+ ions. [http://ac.els-cdn.com/S1075996499901919/1-s2.0-S1075996499901919-main.pdf?_tid=843ae610-28a7-11e7-a31e-00000aacb35e&acdnat=1493008740_a6dead265896beb6ba4f37cf4b555556].]]
[[Image:kappatox1.jpeg|thumb|200px|right|Structure of alpha-toxin. Two separate domains are pictured with N- and C-domains and Zn2+ and possible Ca2+ ions. [http://ac.els-cdn.com/S1075996499901919/1-s2.0-S1075996499901919-main.pdf?_tid=843ae610-28a7-11e7-a31e-00000aacb35e&acdnat=1493008740_a6dead265896beb6ba4f37cf4b555556].]]


[[Image:pore.png|thumb|300px|right|Mechanism of pore formation by PFO on eukaryotic lipid bilayer. Association between lipid bilayer and PFO is greatest on edges of the membrane, where cholesterol is most accessible. [http://www.mdpi.com/2072-6651/7/5/1702/htm.]]
[[Image:pore.png|thumb|300px|right|Mechanism of pore formation by PFO on eukaryotic lipid bilayer. Association between lipid bilayer and PFO is greatest on edges of the membrane, where cholesterol is most accessible. [http://www.mdpi.com/2072-6651/7/5/1702/htm].]]


[[Image:alphatox2.png|thumb|300px|right|The structure of PFO. β-barrels are evident in the four separate domains. Domain 1 and 2 are purple, domain 3 is green and domain 4 is red. [http://www.mdpi.com/2072-6651/7/5/1702/htm].]]
[[Image:alphatox2.png|thumb|300px|right|The structure of PFO. β-barrels are evident in the four separate domains. Domain 1 and 2 are purple, domain 3 is green and domain 4 is red. [http://www.mdpi.com/2072-6651/7/5/1702/htm].]]
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[[Image:alphatox1.png|thumb|300px|right|Alpha-toxin shown interacting with lipid bilayer of eukaryotic membrane. Interactions with ions are shown, denoting the critical role of Ca2+ and Zn2+ in the function of alpha-toxin.  [http://ac.els-cdn.com/S1075996499901919/1-s2.0-S1075996499901919-main.pdf?_tid=843ae610-28a7-11e7-a31e-00000aacb35e&acdnat=1493008740_a6dead265896beb6ba4f37cf4b555556 ].]]
[[Image:alphatox1.png|thumb|300px|right|Alpha-toxin shown interacting with lipid bilayer of eukaryotic membrane. Interactions with ions are shown, denoting the critical role of Ca2+ and Zn2+ in the function of alpha-toxin.  [http://ac.els-cdn.com/S1075996499901919/1-s2.0-S1075996499901919-main.pdf?_tid=843ae610-28a7-11e7-a31e-00000aacb35e&acdnat=1493008740_a6dead265896beb6ba4f37cf4b555556 ].]]


[[Image:oxygen.png|thumb|300px|right|Use of hyperbaric oxygen therapy in wound healing of 53-year-old diabetic patient with spontaneous gas gangrene. Leg was preserved with use of hyperbaric oxygen. Healthy tissue growth can be seen last image. [ttp://www.ijps.org/article.asp?issn=0970-0358;year=2012;volume=45;issue=2;spage=316;epage=324;aulast=Bhutani.]]
[[Image:oxygen.png|thumb|300px|right|Use of hyperbaric oxygen therapy in wound healing of 53-year-old diabetic patient with spontaneous gas gangrene. Leg was preserved with use of hyperbaric oxygen. Healthy tissue growth can be seen last image. [ttp://www.ijps.org/article.asp?issn=0970-0358;year=2012;volume=45;issue=2;spage=316;epage=324;aulast=Bhutani].]]


<br>By Yiyi Ma<br><br>
<br>By Yiyi Ma<br><br>

Revision as of 05:01, 24 April 2017

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Section

47 year-old-man with gas gangrene in the right leg. Picture was taken before hemipelvectomy. Large necrotic blisters of CO2 caused by Clostridium are visible [1].


By Yiyi Ma

Structure of alpha-toxin. Two separate domains are pictured with N- and C-domains and Zn2+ and possible Ca2+ ions. [2].
Mechanism of pore formation by PFO on eukaryotic lipid bilayer. Association between lipid bilayer and PFO is greatest on edges of the membrane, where cholesterol is most accessible. [3].
The structure of PFO. β-barrels are evident in the four separate domains. Domain 1 and 2 are purple, domain 3 is green and domain 4 is red. [4].


Alpha-toxin shown interacting with lipid bilayer of eukaryotic membrane. Interactions with ions are shown, denoting the critical role of Ca2+ and Zn2+ in the function of alpha-toxin. [5].
Use of hyperbaric oxygen therapy in wound healing of 53-year-old diabetic patient with spontaneous gas gangrene. Leg was preserved with use of hyperbaric oxygen. Healthy tissue growth can be seen last image. [ttp://www.ijps.org/article.asp?issn=0970-0358;year=2012;volume=45;issue=2;spage=316;epage=324;aulast=Bhutani].


By Yiyi Ma

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  1. ↑ Hodgkin, J. and Partridge, F.A. "Caenorhabditis elegans meets microsporidia: the nematode killers from Paris." 2008. PLoS Biology 6:2634-2637.
  2. ↑ Bartlett et al.: Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 2013 12:103.



Authored for BIOL 238 Microbiology, taught by Joan Slonczewski, 2017, Kenyon College.

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