Trypanosoma Brucei Gambiense: Difference between revisions
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==Cell Structure, Metabolism and Life Cycle== | ==Cell Structure, Metabolism and Life Cycle== | ||
Similar to microorganisms that fall with the Trypanosoma family, T. Brucei gambiense shares the common tapered ends and the attachment of the long flagellum on its side. | |||
Through a glycolysis metabolic pathway is T. brucei gambiense able to gain the proper nutrients. It will convert glucose into pyruvate that if exposed to aerobic conditions will breakdown to acetyl coenzyme and carbon dioxide. Doing this through the process of the TCA cycle and its reducing equivalents NADH, FADH2, and GTP. | |||
For energy production for carbon sources T. brucei gambiense will use ATP as an intracellular energy source. ATP is induced via catabolic nutrients: carbon, carbohydrates, fatty acids, and amino acids. | |||
==Ecology and Pathogenesis== | ==Ecology and Pathogenesis== | ||
Revision as of 23:34, 15 November 2023
Classification
Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatida; Trypanosomatidae [Others may be used. Use NCBI link to find]
Species
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NCBI: [1] |
Trypanosoma Brucei gambiense
Description and Significance
The genome T. Brucei gambiense is enriched in structural complexity. That is decorated with a flagellum emerging from the posterior end of its basal body. Its elongated body maintains a verbform spindle shape with tapering ends.
Trypanosoma Brucei gambiense's growth is stimulated in the blood of an intermediate host: tsetse fly's midgut, proventriculus, foregut, and salivary glands. But what defines this pathogenesis threat is its complex flagella and flagellar motility within mammalian hosts and the parasitic development in the tsetse fly vector. Although the true depth of contribution of its flagella is unknown due to its vast complexity.
Genome Structure
The linear shaped unicellular parasite can range from 15-30μ long and 1.5-3.5μ in width. With a content genome of 26-megabases, 9068 predicted genes, ~900 pseudogenes and ~1700 T. brucei specific genes. That also contains 11 mega base-size chromosomes.
The DNA in the chromosomes is organized as a supercoiled network that spans about 50 maxicircle DNA molecules. This allows the maxicircle in the DNA to encode about a dozen mitochondrial proteins.
Cell Structure, Metabolism and Life Cycle
Similar to microorganisms that fall with the Trypanosoma family, T. Brucei gambiense shares the common tapered ends and the attachment of the long flagellum on its side.
Through a glycolysis metabolic pathway is T. brucei gambiense able to gain the proper nutrients. It will convert glucose into pyruvate that if exposed to aerobic conditions will breakdown to acetyl coenzyme and carbon dioxide. Doing this through the process of the TCA cycle and its reducing equivalents NADH, FADH2, and GTP.
For energy production for carbon sources T. brucei gambiense will use ATP as an intracellular energy source. ATP is induced via catabolic nutrients: carbon, carbohydrates, fatty acids, and amino acids.
Ecology and Pathogenesis
Habitat; symbiosis; biogeochemical significance; contributions to environment.
If relevant, how does this organism cause disease? Human, animal, plant hosts? Virulence factors, as well as patient symptoms.
References
Author
Page authored by Jamie Montalban Petatan, student of Prof. Bradley Tolar at UNC Wilmington.
