Parvovirus B19: Difference between revisions
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<i>Parvovirus B19</i> is the only member of the <i>Parvoviridae</i> family that has been found to infect human hosts.<ref name=ncbi>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC118081/#:~:text=Parvovirus%20B19%20(B19)%20was%20discovered%20serendipitously%20in%201974%20and%20is,hematologic%20status%20of%20the%20host. Heegaard, E.D. and Brown, K.E. "Human Parvovirus B19." 2002. Clinical Microbiology Review 15(3):485-505.]</ref> It was discovered in 1974, when a research group looking at hepatitis B surface antigens found a serum sample with unexpected results.<ref name=ncbi/> Another lab in Japan described a similar virus in 1979 that they called "Nakatami".<ref name=ncbi/> When compared, the two were found to be identical.<ref name=ncbi/> In 1985 this virus was officially recognized as a member of the <i>Parvoviridae</i> family due to its similarities in genome size and density.<ref name=ncbi/> | <i>Parvovirus B19</i> is the only member of the <i>Parvoviridae</i> family that has been found to infect human hosts.<ref name=ncbi>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC118081/#:~:text=Parvovirus%20B19%20(B19)%20was%20discovered%20serendipitously%20in%201974%20and%20is,hematologic%20status%20of%20the%20host. Heegaard, E.D. and Brown, K.E. "Human Parvovirus B19." 2002. Clinical Microbiology Review 15(3):485-505.]</ref> It was discovered in 1974, when a research group looking at hepatitis B surface antigens found a serum sample with unexpected results.<ref name=ncbi/> Another lab in Japan described a similar virus in 1979 that they called "Nakatami".<ref name=ncbi/> When compared, the two were found to be identical.<ref name=ncbi/> In 1985 this virus was officially recognized as a member of the <i>Parvoviridae</i> family due to its similarities in genome size and density.<ref name=ncbi/> | ||
Infection by Parvovirus B19 (Parvo B19V) causes many diseases, including "fifth disease" in children, aplastic crisis for people with hemolytic anemia, anemia in immunocompromised patients, acute or chronic arthropathy in adults, and fetal hydrops in pregnant women.<ref name=Chen>[https://www-sciencedirect-com.libproxy.kenyon.edu/science/article/pii/S0042682209005303?via%3Dihub. Chen, Z., Guan, W., Cheng, F., Chen, A.Y., and Qiu, J. "Molecular characterization of human parvovirus B19 genotypes 2 and 3" 2009. Virology, 394(2), 276-285.]</ref> | Infection by Parvovirus B19 (Parvo B19V) causes many diseases, including "fifth disease" in children, aplastic crisis for people with hemolytic anemia, anemia in immunocompromised patients, acute or chronic arthropathy in adults, and fetal hydrops in pregnant women.<ref name=Chen>[https://www-sciencedirect-com.libproxy.kenyon.edu/science/article/pii/S0042682209005303?via%3Dihub. Chen, Z., Guan, W., Cheng, F., Chen, A.Y., and Qiu, J. "Molecular characterization of human parvovirus B19 genotypes 2 and 3" 2009. Virology, 394(2), 276-285.]</ref><ref name=Hemauer>[https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-8-1781. Hemauer, A., von Poblotzki, A., Gigler, A., Cassinotti, P., Siegl, G., Wolf, H., and Modrow, S. "Sequence variability among different parvovirus B19 isolates" 1996. Journal of General Virology, 77(8), 1781-1785.]</ref> Changes in the genome are potentially responsible for the wide variation of clinical presentations associated with B19V infection.<ref name=Chen/> | ||
==Section 1== | ==Section 1== | ||
Revision as of 19:43, 6 April 2024
Background
By Grace Potter
Parvovirus B19 is the only member of the Parvoviridae family that has been found to infect human hosts.[1] It was discovered in 1974, when a research group looking at hepatitis B surface antigens found a serum sample with unexpected results.[1] Another lab in Japan described a similar virus in 1979 that they called "Nakatami".[1] When compared, the two were found to be identical.[1] In 1985 this virus was officially recognized as a member of the Parvoviridae family due to its similarities in genome size and density.[1]
Infection by Parvovirus B19 (Parvo B19V) causes many diseases, including "fifth disease" in children, aplastic crisis for people with hemolytic anemia, anemia in immunocompromised patients, acute or chronic arthropathy in adults, and fetal hydrops in pregnant women.[2][3] Changes in the genome are potentially responsible for the wide variation of clinical presentations associated with B19V infection.[2]
Section 1
Include some current research, with at least one figure showing data.
Parvoviridae
Genome Structure
The Parvovirus genome is a single strand of DNA with 5,596 nucleotides, 4,830 of which are coding regions.[1] This region contains 2 large open reading frames.[1] One large non-structural protein is coded by one open reading frame, and the second reading frame codes for 2 capsid proteins.[1]
Section 3
Include some current research, with at least one figure showing data.
Section 4
Conclusion
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Heegaard, E.D. and Brown, K.E. "Human Parvovirus B19." 2002. Clinical Microbiology Review 15(3):485-505.
- ↑ 2.0 2.1 Chen, Z., Guan, W., Cheng, F., Chen, A.Y., and Qiu, J. "Molecular characterization of human parvovirus B19 genotypes 2 and 3" 2009. Virology, 394(2), 276-285.
- ↑ Hemauer, A., von Poblotzki, A., Gigler, A., Cassinotti, P., Siegl, G., Wolf, H., and Modrow, S. "Sequence variability among different parvovirus B19 isolates" 1996. Journal of General Virology, 77(8), 1781-1785.
- ↑ Jalali, Sedigheh, Farhardi, Ali, Dehbidi, G.R., Farjadian, Shirin, Sharifzadeh, Sedigheh, Ranjbaran, Reza, Seyyedi, Noorossadat, Namdari, Sepide and Behzad-Behbahani, Abbas. "The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases" 2022. Interdisciplinary Perspectives on Infectious Diseases.
- ↑ Ros, Carlos, Bieri, Jan, and Leisi, Remo. "The VP1u of Human Parvovirus B19: A Multifunctional Capsid Protein with Biotechnological Applications" 2020. Viruses, 12(12), 1463.
- ↑ Rinkūnaitė, I., Šimoliūnas, E., Bironaitė, D., Rutkienė, R., Bukelskienė, V., Meškys, R., and Bogomolovas, J. "The Effect of a Unique Region of Parvovirus B19 Capsid Protein VP1 on Endothelial Cells" 2021. Biomolecules, 11(4), 606.
Authored for BIOL 238 Microbiology, taught by Joan Slonczewski,at Kenyon College,2024
